echet98 ConferenceBiologically Active Heterocycles/Target Oriented Synthesis

Keynote; Synthesis and Methodology; Biologically Active Heterocycles/Target Oriented Synthesis ; Computational Heterocyclic Chemistry; Mechanistic Studies/Physical Properties
Enantioselective binding of an acridine substituted Troeger s Base to Calf Thymus DNA

Tatibouet, Arnaud; Demeunynck, Martine; Lhomme, Jean; Dheu-Andries, Marie-Louise; Charapoff, Denis; Vatton, Pierre;
Poster 022
Received: 22 Apr 1998

keywords: nitrogen heterocycle; acridine; Troeger's base; DNA recognition DNA conformation;

Synthesis of Modified Nucleosides by 1,3-Dipolar Cycloaddition of C-Alcoxycarbonyl Nitrones

Chiacchio, Ugo; Corsaro, Antonino; Gumina, Giuseppe; Rescifina, Antonio; Romeo, Giovanni; Iannazzo, Daniela; Piperno, Anna;
Article 025
Received: 24 Apr 1998

keywords: 1,3-dipolar nitrone cycloaddition; isoxazolidines; nucleoside analogues;

Syntheses of New Cephalosporins as Potent Antibacterial Agents

Hwu, Jih Ru; Tsay, Shwu-Chen; Liao, Shu-Mei; Hakimelahi, Shahram;
Article 026
Received: 01 May 1998

keywords: Isodethiaazacephem; Mesylate; Triflate; [1,4]-Elimination; Antibacterial; b-Lactam;

A Novel Five-Step Route to the Synthesis of Psilocin from Indole-3-carbaldehyde

Masanori Somei; Fumio Yamada; Mayumi Tamura;
Poster 039
Received: 11 May 1998

keywords: psilocin; Indole-3-carbaldehyde; 4-Benzyloxyindole-3-carbaldehyde; 4-Benzyloxyindole-3-acetonitrile; 4-Benzyloxytryptamine;

Strict Geometric Control in the Synthesis of Porphyrin-Ligand Supramolecular Systems

Schultz, Austin C.; Johnston, Martin R.; Warrener, Ronald N.; Gunter, Maxwell J.;
Article 077
Received: 14 May 1998

keywords: cycloaddition; porphyrin; ligand; phenanthroline; stereoselectivity;

Synthesis and Antimicrobial Activity of Some 2-Alkyl-5,6-diphenylimidazo[2,1-b]thiazolidin-3-ones

Koos, Miroslav; Gajdos, Jan; Steiner, Bohumil;
Poster 082
Received: 14 May 1998

keywords: Imidazo[2,1-b]thiazolidin-3-ones; antimicrobial activity;

Synthesis of Beta-carboline Derivatives and Their Interaction with a DNA Oligomer

Konakahara, Takeo*; Ozaki, Tomokazu; Komatsu, Harunobu; Ohta, Yuichi; Takeuchi, Hiroki; Tamura, Sanae;
Poster 084
Received: 14 May 1998

keywords: DNA-intercalator; beta-carbolines; binding constant; Scatchard plot; Synthesis;

Synthesis of Novel Heterocyclic Systems from a-(2-R-6-R1-5-halogenopyrimidin-4-yl)-2-azahetarylacetonitriles. New Potential Anticancer Agents.

Fursy, Tamara; Nemazany, Alexei; Rice, Kenner C.;
Poster 090
Received: 14 May 1998

keywords: condensed pyrimidines; new heterocyclic ring systems; nucleophilic substitution; hetarylacetonitriles; intermolecular cyclization; anticancer agents;

Inhibition studies of Porphobilinogen Synthase from Escherichia coli using diacids

Jarret, Caroline; Bobalova, Janette; Stauffer, Frédéric; Henz, Matthias; Neier, Reinhard;
Article 103
Received: 15 May 1998

keywords: Porphobilinogen; Porphobilinogen Synthase; inhibition; diacids; 5-aminolevulinate; mechanism;

Synthesis of 3-substituted analogues of levulinic acid via Baylis-Hillman and Mukaiyama reactions. Potential inhibitors of Porphobilinogen Synthase.

Bobál', Pavel; Neier, Reinhard;
Article 104
Received: 15 May 1998

keywords: Porphobilinogen Synthase; levulinate; Mukaiyama; Bailys-Hillman; Mitsunobu;

Inhibition of porphobilinogen synthase (PBG-synthase) by 4,6-dioxoheptanoic acid (1) and related compounds

Stauffer, Frédéric; Jarret, Caroline; Engeloch, Thomas; Henz, Matthias; Bobalova, Janette; Neier, Reinhard;
Poster 107
Received: 15 May 1998

keywords: Porphobilinogen; porphobilinogen synthase; inhibition; 1,3-diketone; 5-aminolevulinate;

Regioselective bromination of the 16-hydroxymethyl-3-methoxyestra-1,3,5(10)-trien isomers

Mernyák, Erzsébet; Schneider, Gyula; Wölfling, János;
Poster 115
Received: 15 May 1998

keywords: steroids; bromination; neighbouring group participation;

New pyrimidine cyclonucleosides with hydrogenated aglycone: synthesis and structure

Shutalev, Anatoly D.; Gurskaya, Galina V.;
Poster 116
Received: 15 May 1998

keywords: 2,3-O-isopropylideneribofuranosylamine; isothiocyanatoaldehydes; pyrimidine cyclonucleosides; 3-(D-ribosyl)-4-hydroxyhexahydropyrimidine-2-thiones;

Molecular imprinted polymers for the chiral separation of pharmaceutically relevant heterocycles: First results of the separation of the anti-Alzheimer drug Galanthamine

Jordis, Ulrich; Rizzi, Andreas; Grohmann, Franz;
Poster 118
Received: 16 May 1998

keywords: Molecular imrinted polymers, MIP, chiral separation, HPLC, CE, Galanthamine;