Posts Tagged ‘lower energy conformations’

Why is the Sharpless epoxidation enantioselective? Part 1: a simple model.

Sunday, December 9th, 2012

Sharpless epoxidation converts a prochiral allylic alcohol into the corresponding chiral epoxide with > 90% enantiomeric excess[cite]10.1021/jo00369a032[/cite],[cite]10.1021/jo00360a058[/cite]. Here is the first step in trying to explain how this magic is achieved.

(more…)