Archive for December 14th, 2011

Molecular gymnastics in 2+2 cycloadditions.

Wednesday, December 14th, 2011

In this earlier post, I described how the stereochemistry of π22 cycloadditions occurs suprafacially if induced by light, and how one antarafacial component appears if the reaction is induced by heat alone. I also noted how Woodward and Hoffmann (WH) explained that violations to their rules were avoided by mandating a change in mechanism requiring stepwise pathways with intermediates along the route. Here I illustrate how the stereochemistry of a thermal π22 cycloaddition can indeed avoid an antarafacial component by performing appropriate gymnastic contortions instead of a mechanistic change (a WH violation certainly in the letter of their law, if not their spirit).
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