[Home Page ] [Introduction ] [Origins of the G-Quadruplex ] [The Fight Against Cancer ] [Conclusion ] [Glossary ][References ] [About the author]

References

General References

1. McEachern et al,Telomeres and Their Control, Annu. Rev. Genet. 34, 331-350, (2001)
2. Neidle and Parkinson, Telomere Maintenance as a Target For Anticancer Drug Discovery, Nat Rev. 1, 383 - 392, (2002)
3. The Telomere, by David Kipling. OUP (1995)
4. Pitts and Corey, The telomerase Challenge-an unusual problem in drug discovery, DDT, 4, 155-161, (1999)
5. Shay et al, Telomerase and Cancer, Hum Mol Genet, 10, 677-85, (2001)
6. Kipling D, Telomerase: immortality enzyme or oncogene? Nat Genet, 9, 104-106, (1995)
7. - Dr Fossel - The Aging Research Institute, www.antiaging-europe.com
8. Good General Genetics: Russell P J, Ed. 1996 Genetics. p 375 R. R. Donelley & Sons Co.

Specialized References

9. Harley et al, Nature, 345, 458-460, (1990)
10. Wright et al, Normal human chromosomes have long G-rich teloemric overhangs at one end. Genes Dev, 11, 2801-2809 (1997)
11. Muller, H. J., The remaking of chromosomes, Collecting Net, 8, 182-195 (1938)
12. McClintock B., The stability of broken ends of chromosomes in Zea Mays, Genetics, 26, 234-282, (1941)
13. Griffith et al, Mammalian telomeres end in large duplex loop. Cell, 4, 503-514, (1999)
14. Hastie et al, Telomere reduction in human colorectal carcinoma and with aging. Nature. 346, 866-68, (1990)
15. Kim et al, Specific Association of Human Telomerase activity with immortal cells and Cancer. Science, 266, 2011-2015, (1994)
16. Patel et al, Clinical Usefulness of telomerase activation and telomere length in Head and Neck Cancer, Head and Neck, 24(12), 1060-1067, (2002)
17. Broccoli et al, Telomerase Activity in Normal and Malignant cells. Proc. Natl.Acad. Sci. USA. 92, 9082-9086, (1994)
18. Feng et al, The RNA component of Human Telomerase. Science, 269, 1236, 1241, (1995)
19. Morin et al, The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesises TTAGGG repeats., Cell, 59, 521-529, (1989)
20. Wilkie et al, A truncated human chromosome 16 associated with alpha thalassaemia is stabilized by addition of telomeric repeat (TTAGGG)n, Nature, 346, 868-871, (1990)
21. Bryan et al, Telomere elongation in immortal human cells without detectable telomerase activity. EMBO. J, 14, 4240-4248, (1997)
22. Parkinson et al, Do telomerase Antagonists Represent a Novel Anti-Cancer Strategy? Br. J. Cancer. 73, 1-4, (1996)
23. Rhyu M. S., Telomeres, Telomerase and Immortality. J. Natl. Cancer. Inst. 87, 884-894
24. Damm et al, A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J, 20, 6958-6968 (2001)
25. Norton et al, Inhibition of Human Telomerase Activity by Peptide Nucleic Acids, Nature Biotechnol. 14, 615-619, (1996).
26. Zahler et al, Inhibition of Telomerase by G-quartet DNA Structures, Nature, 350, 718-720, (1991).
27. Siddiqui-Jain et al, Direct Evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proc. Natl. Acad. Sci. USA, 99, 11593-11598, (2002)
28. Meyne et al, Conservation of the human telomere sequence (TTAGGG)n among vertebrates, Proc. Natl, Acad, Sci, USA, 86, 7049-7053, (1989)
29. McElligot et al, The Terminal DNA structure of mammalian chromosomes. ENBO J. 16, 3705-3714, (1997)
30. Hahn et al, Inhibition of telomerase limits the growth of human cancer cells. Nat. Med. 5, 1164-1170, (1999)
31. Wright et al, Telomerase activity human germline and embryonic tissues and cells, Dev. Genet. 18, 173-179, (1996)
32. White et al, Telomerase Inhibitors, TRENDS in Biotech, 19, 114-121, (2001)
33. Feng et al, The RNA component of human telomerase. Science, 269, 1236-1241, (1995)
34. Henderson et al, Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs. Cell, 51, 899-908
35. Hardin et al, Monovalent cation induced structural transitions in telomeric DNAs, Biochemistry, 30, 4460-4472.
36. Williamson et al, G-quartet structures in telomeric DNA. Annu Rev Biophys Biomol Struct 23, 703-730, (1994)
37. Zahler et al, Inhibition of telomerase by G-quartet DNA structure, Nature, 350, 718-720, (1991)
38. Williamson et al, Monovalent cation induced structure of telomeric DNA: the G-quartet model, Cell, 59, 871-880, (1989)
39. Philips et al, The crystal structure of a parallel stranded guanine tetraplex at 0.95A resolution. J Mol Biol 17, 171-182, (1997)
40. Sun et al, Inhibition of human telomerase by a G-quadruplex-interactive compound, J. Med. Chem. 40, 2113-2118, (1997)
41. Hurley et al, G-quadruplexes as targets for drug design. Pharm. And Therapeutics, 85, 141-158, (2000)
42. Wheelhouse et al, J. Am. Chem. Soc. 120, 3261-3252
43. Read et al, Structure based design of selective and potent G-quadruplex-mediated telomerase inhibitors. Proc. Natl. Acad. Sci. USA. 98, 4844-4849 (2001)
44. Gowan et al, A G-quadruplex-interactive potent small molecule inhibitor of telomerase exhibiting in vivo and in vitro anti-tumour activity, Mol. Pharmacol, 61, 1154-1162, (2002)

Images

• Cover Chemical & Engineering News , 2002 American Chemical Society
• Fig 1. www.exn.ca - The genetic evolution is underway
• Fig 2. Kathy Burgoine
• Fig 3. Adapted from Pearson Education, inc., publishing as Benjamin Cummings
• Fig 4. adapted from Mapping Our Genes The Genome Projects: How Big, How Fast? U.S. Congress, Office of Technology Assessment
• Fig 5. Jeanne Kelly, newscentre.cancer.gov
• Fig 6. Adapted from www.geneinformation.org/images
• Fig 7. Klappe et al, Telomere Biology in human aging and aging syndromes, Mechanisms of Aging and Development, 122, 695-712, (2001)
• Fig 8. Adapted from Blasco M. A. et al, Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA, Cell, Vol. 91, 25-34, 1997
• Fig. 9 Kathy Burgoine
• Fig 10. adapted from www.biology.ucsc.edu
• Fig. 11 Kathy Burgoine
• Fig. 12 Adapted from Pitts et al, The telomerase Challenge, DDT, 4, 156, (1999)
• Fig 13. Adapted from Stephen Neidle, www.chemsoc.org
• Fig 14. www-shankar.ch.cam.ac.uk/research
• Fig 15. Adapted from DNA and its associated processes a targets for cancer therapy, Nature Reviews Cancer 2; 188-200 (2002)
• Fig 16. Neidle and Parkinson, Telomere Maintenance as a Target For Anticancer Drug Discovery, Nat Rev. 1, 389, (2002)
• Fig 17. Stephen Neidle, www.chemsoc.org
• Fig 18. Stephen Neidle, www.chemsoc.org
• Fig 20. Neidle and Parkinson, Telomere Maintenance as a Target For Anticancer Drug Discovery, Nat Rev. 1, 389, (2002)