We found that thiyl radical addition-cyclization of the hydroximates smoothly proceeded to give the cyclized products. The newly found radical cyclization provides a synthetically useful method for the construction of butyrolactones widely found in biologically active natural products.

1) Introduction [click here for details]

2) Thiyl Radical Addition-Cyclization of the Z-Hydroximates [click here for details]

3) Conversion of the Cyclic Hydroximates to the Lactones [click here for details]

4) Synthesis of Oxo-parabenzlactone [click here for details]

5) Conclusion [click here for details]

6) Acknowledgments and References [click here for details]