|[Molecules: 2] [Related articles/posters: 074 102 005 035 107 ]|
Who can model new quinolone-type heterocycles as potential
|Keywords||Quinolones / Gyrase inhibitors|
|Invitation to molecular modelling|
|Download the structures||Click here to open the overlap.tgf file in ISIS/Draw.
Click here to see the reaction scheme.
|The synthesis of members of a new heterocyclic ring system (thieno[2',3':4,5]thieno[3,2-b]pyridine) is described. Compound 9 (and fluorinated derivatives thereof) seem to have a similar spatial arrangement of functional groups as the "mother" of third generation quinolones, norfloxacine. Readers might have the resources and expertise to compare the two structures.|
Compound 9 - not containing the fluorine atom depicted in the above comparison with Norfloxacin - showed no antibacterial activity to warrant further development, but calculations might justify the effort to place a fluorine atom at the desired position of the molecule.
You can also view the scheme here as a jpeg