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The thermolytic degradation of ethyl malonates of type 3 gives the ethyl acetates 4. With the 2-quinolone ring system this class of compounds shows manifold pharmacological activities .
Methyl malonates 3 having as substituent R1 a nitro group form under thermolytic conditions by loss of carbon dioxide and methanol isoxazoles of type 7. The thermolysis reactions to 4 and 7 have been studied by differential scanning calorimetry (DSC) .
The Wittig- or Grignard reaction of 2,2-disubstituted 1,3-dicarbonyl carbo- or heterocycles 5 with alkyl-triphenylphosphonium halides leads to 1-alkylidene-3-oxo compounds 6. This compound class was recently found to show antiviral activities .
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