[1] A.R. Battersby, C.J.R. Fookes, G.W.J. Matcham, E. McDonald, Nature (London) 1980, 285, 17.

[2] A.R. Battersby, Natural Product Reports 1987, 4, 77.

[3] Chlorophylles. In: Encyclopædia Universalis, Paris: 1970, p. 409-411.

[4] R. Willstätter, A. Hocheder, Liebigs Ann.Chem. 1907, 354, 205.

[5] A. Stoll, Wiedemann, Helv.Chim.Acta 1933, 16, 183.

[6] The Photosynthetic Reaction Center', Academic Press, New York, 1993,

[7] M.F. Perutz, Sci.Am. 1978, 239, 92.

[8] F.P. Guengerich, T.L. MacDonald, Acc.Chem.Res. 1984, 17, 9.

[9] W.-D. Woggon, Nachr.Chem.Tech.Lab. 1988, 36, 890.

[10] A. Pfaltz, Chimia 1990, 44, 203.

[11] P.E. Rouvière, R.S. Wolfe, J.Biol.Chem. 1988, 263, 7913.

[12] R. Ellermann, R. Hedderich, R. Böcher, R.K. Thauer, Eur.J.Biochem. 1988, 172, 669.

[13] Friedmann, H.C., Klein, A. and Thauer, R.K. Biochemistry of coenzyme F430, a nickel porphinoid involved in methanogenesis. In: Biosynthesis of Tetrapyrroles, edited by Jordan, P.M. Amsterdam: Elsevier, 1991, p. 139-154.

[14] B. Kräutler, Chimia 1987, 41, 277.

[15] C. Walsh, in 'Enzymatic Reaction Mechanisms', Freeman, San Francisco, 1979,

[16] D. Shemin, D. Rittenberg, J.Biol.Chem. 1946, 166, 627.

[17] J. Wittenberg, D. Shemin, J.Biol.Chem. 1950, 185, 103.

[18] D. Shemin, J. Wittenberg, J.Biol.Chem. 1951, 192, 315.

[19] D. Shemin, C.S. Russell, J.Am.Chem.Soc. 1953, 75, 4873.

[20] D. Shemin, C.S. Russell, T. Abramsky, J.Biol.Chem. 1955, 215, 613.

[21] J.E. Falk, E.I.B. Dresel, E. Rimington, Nature (London) 1953, 172, 292.

[22] A. Neuberger, J.J. Scott, Nature (London) 1953, 172, 1093.

[23] Shemin, D. From Glycine to Heme. In: From Cyclotrons to Cytochromes. Essay in Molecular Biology and Chemistry, edited by Kaplan, N.O. and Robinson, A. New York: Academic Press, 1982, p. 117-131.

[24] D. Shemin, BioEssays 1989, 10(1), 30.

[25] S.R. Dickmann, J.Mol.Evol. 1977, 10, 251.

[26] N.H. Georgopadakou, A.I. Scott, J.Theor.Biol. 1977, 69, 381.

[27] Larkum, A.W.D. The Evolution of Chlorophylls. In: Chlorophylls, edited by Scheer, H. Boca Raton: CRC Press, 1991, p. 367-383.

[28] Beale, S.I. and Weinstein, J.D. Biosynthesis of 5-Aminolevulinic Acid in Phototrophic Organisms. In: Chlorophylls, edited by Scheer, H. Boca Raton: CRC Press, 1991, p. 385-406.

[29] S. Beale, S. Gough, S. Granick, Proc.Natl.Acad.Sci.U.S.A. 1975, 72, 2719.

[30] J.D. Weinstein, S.I. Beale, J.Biol.Chem. 1983, 258, 6799.

[31] S.M. Mayer, S.I. Beale, Plant Physiol. 1992, 99, 482.

[32] F.J. Leeper, Natural Product Reports 1989, 6, 171.

[33] F.J. Leeper, Natural Product Reports 1985, 2, 19.

[34] F.J. Leeper, Natural Product Reports 1985, 2, 561.

[35] A.I. Scott, Tetrahedron 1994, 50, 13315.

[36] F. Blanche, B. Cameron, J. Crouzet, L. Debussche, D. Thibaut, M. Vuilhorgne, F.J. Leeper, A.R. Battersby, Angew.Chem.Int.Edit. 1995, 34, 383.

[37] A. Eschenmoser, Chem.Soc.Rev. 1976, 5, 377.

[38] G. Ksander, G. Bold, R. Lattmann, C. Lehmann, T. Früh, Y.-B. Xiang, K. Inomata, H.-P. Buser, J. Schreiber, E. Zass, A. Eschenmoser, Helv.Chim.Acta 1987, 70, 1115.

[39] A. Eschenmoser, Angew.Chem. 1988, 100, 5.

[40] S. Drenkard, J. Ferris, A. Eschenmoser, Helv.Chim.Acta 1990, 73, 1373.

[41] A. Eschenmoser, E. Loewenthal, Chem.Soc.Rev. 1992, 21, 1.

[42] M. Calvin, Perspect.Biol.Med. 1963, 13, 45.

[43] K. Decker, K. Jungermann, R.K. Thauer, Angew.Chem. 1970, 82, 152.

[44] G.H. Cookson, C. Rimington, Biochem.J. 1954, 57, 476.

[45] D. Mauzerall, J.Am.Chem.Soc. 1960, 82, 2605.

[46] D. Mauzerall, J.Am.Chem.Soc. 1960, 82, 2601.

[47] H. von Dobeneck, B. Hansen, E. Vollmann, Z.Naturforsch.B 1972, 27, 922.

[48] B. Franck, H. Stratman, Heterocycles 1981, 15, 919.

[49] A. Eschenmoser, Ann.N.Y.Acad.Sci. 1986, 471, 108.

[50] D.L. Nandi, D. Shemin, J.Biol.Chem. 1968, 243, 1236.

[51] P.M. Jordan, J.S. Seehra, J.Chem.Soc., Chem.Commun. 1980, 240.

[52] P.M. Jordan, J.S. Seehra, FEBS Lett. 1980, 114(2), 283.

[53] Neier, R. Chemical Synthesis of Porphobilinogen and Studies of its Biosynthesis. In: Advances in Nitrogen Heterocycles Volume 2, edited by Moody, C.J. Greenwich: JAI Press Inc., 1996, p. 35-146.

[54] A.R. Chaperon, T.M. Engeloch, R. Neier, Angew.Chem.Int.Ed. 1998, 37, 358.

[55] Z. Zaman, P.M. Jordan, M. Akhtar, Biochem.J. 1973, 135, 257.

[56] M.M. Abboud, M. Akhtar, J.C.S.Chem.Comm. 1976, 1007.

[57] E.K. Jaffe, G.D. Markham, Biochem. 1987, 26, 4258.

[58] E.K. Jaffe, G.D. Markham, L.S. Rajagopalan, Biochem. 1990, 29, 8345.

[59] G.V. Louie, P.D. Brownlie, R. Labert, J.B. Cooper, T.L Blundell, S.P. Wood, M.J. Warren, S.C. Woodcock, P.M. Jordan, Nature (London) 1992, 359, 33.

[60] E.K. Jaffe, J.Bioenerg.Biomembr. 1995, 27, 169.

[61] H.L. Carrell, J.P. Glusker, L. Shimoni, L.J. Keefe, C. Afshar, M. Volin, E.K. Jaffe, Acta Crystallogr D 1996, 52, 419.

[62] P.T. Erskine, N. Senior, S. Maignan, J. Cooper, R. Lambert, G. Lewis, P. Spencer, S. Awan, M. Warren, I.J. Tickle, P. Thomas, S.P. Wood, P.M. Shoolingin-Jordan, Protein Science 1997, 6, 1774.

[63] E.K. Jaffe, S. Ali, L.W. Mitchell, K.M. Taylor, M. Volin, G.D. Markham, Biochemistry 1995, 34, 244.

[64] L.W. Mitchell, E.K. Jaffe, Arch.Biochem.Biophys. 1993, 300, 169.

[65] E.K. Jaffe, Comments Inorg.Chem. 1993, 15, 67.

[66] R.M. Petrovich, S. Litwin, E.K. Jaffe, J.Biol.Chem. 1996, 271, 8692.

[67] E.K. Jaffe, W.K. Abrams, H.X. Kaempfen, K.A. Harris Jr., Biochemistry 1992, 31, 2113.

[68] E.K. Jaffe, M. Volin, C.B. Myers, W.R. Abrams, Biochemistry 1994, 33, 11554.

[69] R. Lüönd, in 'Untersuchungen zum Enzymmechanismus der d-Aminolävulinsäure-Dehydratase aus Rhodopseudomonas Spheroides, Inaugural-Dissertation, Universität Freiburg in der Schweiz, Diss. Nr. 1001', Multiprint, Fribourg SA, 1991,

[70] R.M. Lüönd, J. Walker, R. Neier, J.Org.Chem. 1992, 57, 5005.

[71] P. Nayar, N.J. Stolowich, A.I. Scott, Bioorg.Med.Chem.Lett. 1995, 5, 2105.

[72] D. Appleton, F.J. Leeper, J.Chem.Soc.,Chem.Commun. 1996, 303.

[73] D. Appleton, A.B. Duguid, S.K. Lee, Y.J. Ha, H.J. Ha, F.J. Leeper, J.Chem.Soc.,Perkin Trans 1 1998, 89.

[74] P. Spencer, P.M. Jordan, Biochem.J. 1995, 305, 151.

[75] J.S. Seehra, P.M. Jordan, Eur.J.Biochem. 1981, 113, 435.

[76] J. Bellamine, Unpublished Results, 1990.

[77] D. Shemin, Vitamins and Hormones 1968, 26, 357.

[78] D. Shemin, Naturwissenschaften 1970, 57, 185.

[79] Shemin, D. d-Aminolevulinic Acid Dehydratase (Rhodopseudomonas spheroides). In: Methods in Enzymology Vol. XVII Part A, edited by Colowick, S.P. and Kaplan, N.O. New York: Academic Press, 1970, p. 205-211.

[80] P.M. Jordan, P.N.B. Gibbs, Biochem.J. 1985, 227, 1015.

[81] Jordan, P.M. The Biosynthesis of 5-Aminolevulinic Acid and Its Transformation into Coproporphyrinogen in Animals and Bacteria. In: Biosynthesis of Heme and Chlorophylls, edited by Dailey, H.A. New York: McGraw-Hill, 1990, p. 55-121.

[82] Jordan, P.M. The biosynthesis of 5-aminolaevulinic acid and its transformation into uroporphyrinogen III. In: Biosynthesis of Tetrapyrroles, edited by Jordan, P.M. Amsterdam: Elsevier, 1991, p. 1-66.

[83] C. Jarret, J. Bobalova, F. Stauffer, M.E. Henz, R. Neier, ECHET98 1998, 103.

[84] F. Stauffer, C. Jarret, T. Engeloch, M. Henz, J. Bobalova, R. Neier, ECHET98 1998, 107.

[85] E.M. Gordon, R.W. Barrett, W.J. Dower, S.P.A. Fodor, M.A. Gallop, J.Med.Chem. 1994, 37(10), 1385.

[86] R. Lüönd, Unpublished Results, 1990.

[87] R.V. Hoffman, H.O. Kim, J.C. Lee, J.Org.Chem. 1994, 59, 1933.

[88] B.C. Ranu, S. Bhar, J.Chem.Soc.,Perkin Trans 1 1992, 365.

[89] K. Sunggak, H.A. Kyo, J.Org.Chem. 1984, 49, 1717.

[90] P.J. Clewlow, A.H. Jackson, J.Chem.Soc.,Perkin Trans 1 1990, 1925.

[91] L.K.P. Lam, R.A.H.F. Hui, J.B. Jones, J.Org.Chem. 1986, 51, 2047.

[92] S.J. Danishefsky, W.H. Pearson, B.E. Segmuller, J.Am.Chem.Soc. 1985, 107, 1280.

[93] S.J. Danishefsky, C. Maring, J.Am.Chem.Soc. 1985, 107, 7762.

[94] W. Lehnert, Tetrahedron Lett. 1970, 4723.

[95] W. Lehnert, Synthesis 1974, 667.

[96] W. Lehnert, Tetrahedron 1972, 28, 663.

[97] C. Dominguez, A.G. Csaky, J. Plumet, Tetrahedron Lett. 1991, 32, 4183.

[98] L. Herbrandson, D. Van Heyningen, J.Am.Chem.Soc. 1946, 68, 1281.

[99] M.S. Brown, H. Rapport, J.Org.Chem. 1963, 28, 3261.

[100] R.B. Gammill, L.T. Bell, S.A. Nash, J.Org.Chem. 1984, 49, 3039.

[101] H. Newman, R.B. Angier, J.Org.Chem. 1966, 31, 1451.

[102] A. Fischli, J.J. Daly, Helv.Chim.Acta 1980, 63, 1628.

[103] M. Yamashita, Y. Kato, R. Suemitsu, Chem.Lett. 1980, 847.

[104] E.R. Koft, T.A. Broadbent, Org.Prep.Proced.Int. 1988, 20, 199.

[105] A.W. Konradi, S.J. Kemp, S.F. Pedersen, J.Am.Chem.Soc. 1994, 116, 1316.

[106] I. Ojima, T. Kogure, Y. Nagai, Tetrahedron Lett. 1972, 5035.

[107] I. Ojima, T. Kogure, Organometallics 1982, 1, 1390.

[108] Y. Nagai, Org.Prep.Proced.Int. 1980, 12, 13.

[109] M.P. Carmody, M.J. Cook, N.L. Dassanayake, A.R. Katritzky, P. Linda, R.P. Tack, Tetrahedron 1976, 32, 1767.

[110] A. Ishigaki, T. Shono, Bull.Chem.Soc.Jpn. 1974, 47, 1467.

[111] G. Piancateli, E. Castagnino, Heterocycles 1985, 23, 667.

[112] M. Fetizon, M.T. Montaufier, J. Rens, J.Chem.Res.(S) 1982, 9.

[113] H. Bertschy, A. Meunier, R. Neier, Angew.Chem. 1990, 102, 828.

[114] S.F. McDonald, Can.J.Chem. 1974, 52, 3257.

[115] T. Mukaiyama, K. Banno, K. Narasaka, J.Am.Chem.Soc. 1974, 96, 7503.

[116] A.B. Baylis, M.E.D. Hillman, Ger.Patent 1972, 2155113,

[117] J. Auge, N. Lubin, A. Lubineau, Tetrahedron Lett. 1994, 35, 7947.

[118] A.G.M. Barrett, A. Kamimura, J.Chem.Soc., Chem.Commun. 1995, 1755.

[119] D. Basavaiah, R.S. Hyma, Tetrahedron 1996, 52, 1253.

[120] A.B. Charette, B. Côté, S. Monroc, S. Prescott, J.Org.Chem. 1995, 60, 6888.

[121] D. Basavaiah, S. Pandiaraju, P.K.S. Sarma, Tetrahedron Lett. 1994, 35, 4227.

[122] D. Seebach, Angew.Chem. 1979, 91, 259.

[123] S.E. Drewes, G.H.P. Roos, Tetrahedron 1988, 44, 4653.

[124] H.M.R. Hoffmann, U. Eggert, W. Poly, Angew.Chem.Int.Ed. 1987, 26, 1015.

[125] M.G. Adlington, M. Orfanopoulos, J.K. Fry, Tetrahedron Lett. 1976, 2955.

[126] S. Kobayashi, SYNLETT 1994, 689.

[127] J. Pataki, R.G. Harvey, J.Org.Chem. 1987, 52, 2226.

[128] D.N. Kursanov, Z.N. Parnes, N.M. Loim, Synthesis 1974, 633.

[129] H.M. Hoffmann, J. Rabe, J.Org.Chem. 1985, 50, 3849.

[130] E.J. Corey, C.U. Kim, M. Takeda, Tetrahedron Lett. 1972, 4339.

[131] T. Sakai, K. Miyata, M. Utaka, A. Takeda, Tetrahedron Lett. 1987, 28, 3817.

[132] R. Annunziata, M. Benaglia, M. Cinquini, F. Cozzi, L. Raimondi, J.Org.Chem. 1995, 60, 4697.

[133] J. Reiter, L. Pongo, T. Somorai, I. Pallagi, Monatsh.Chem. 1990, 121, 173.

[134] F. Gaudemar-Bardone, M. Mladenova, R. Couffignal, Synthesis 1985, 1043.

[135] S. Eskola, Suom.Kemistil.B 1955, 28, 87.

[136] C.N. Robinson, L.J. Wiseman, C.D. Slater, Tetrahedron 1989, 45, 4103.

[137] W.R. Kirner, G.H. Richter, J.Am.Chem.Soc. 1929, 51, 3131.

[138] T. Miyakoshi, H. Omichi, S. Saito, Nippon Kagaku Kaishi 1980, (1), 44, CA 92: 146214.

[139] S. Iriuchijima, T. Ino, T. Ootsu, Jpn.Kokai Tokkyo Koho 1991, JP 05,306,256, CA 120: 216 724.