Overview: reactions with cyclic-BMMA-type reagents

Starting from appropriate amino esters or nitriles a large number and variety of novel tetracyclic heterocycles are accessible in good yields (65-85%), proving the broad scope of this cyclization method.




m=1-2; n=1-3; X=C,S,N; Y=O,S; Z=O,NH;


Example of a thiazole-anellation: