Enantiopure or enantioenriched (scalemic) molecules
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CAS records 64,100,817 substances, 63,295,827 sequences and 51,725,863 reactions
- What proportion involve chiral species?
- What proportion of the chiral species are scalemic?
- i.e. aspiring to an (partial or complete) excess of one enantiomer over the other
- reflected in chiroptical (CO) properties
- There are reported CO properties for:
- 1,185,523 (1.8%) entries in Reaxys (Beilstein)
- What proportion directly correlated with the absolute configuration (AC)?
- No reported CO properties for most chiral molecules (>30M?)
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- Because the molecules have only been characterised in racemic rather than scalemic form?
- Because they have never been measured?