Synthesis of Scalemic molecules
- Each year this department synthesises :
- ~200 asymmetric (disymmetric) chiral molecules
- aspiring to a (partial or complete) excess of one enantiomer over the other (scalemic)
- Absolute scalemic configuration (AC) is essential to:
- understanding the mechanistic origins of scalemic excess
- leading to the prospect of rational design
- Patents, FDA approval, publications, etc etc!
- The ACs of only ~5-10 are established by crystallography,
- Leaving ~190 whose ACs are otherwise inferred or determined
- Question: how certain are you the ACs of these ~190 scalemic molecules are correctly assigned?
This talk is aimed at those whose molecule(s) are in this group.
Or who want to check up on literature assignments!