{"id":7822,"date":"2012-09-25T15:34:13","date_gmt":"2012-09-25T14:34:13","guid":{"rendered":"http:\/\/www.ch.imperial.ac.uk\/rzepa\/blog\/?p=7822"},"modified":"2013-01-04T06:48:32","modified_gmt":"2013-01-04T06:48:32","slug":"oxime-formation-from-hydroxylamine-and-ketone-part-2-elimination","status":"publish","type":"post","link":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/?p=7822","title":{"rendered":"Oxime formation from hydroxylamine and ketone. Part 2: Elimination."},"content":{"rendered":"
\n

This is the follow-up to the previous post<\/a> exploring a typical nucleophilic addition-elimination reaction. Here is the elimination step, which as before requires proton transfers. We again adopt a cyclic mechanism to try to avoid the build up of charge separation during those proton movements.<\/p>\n

\"\"<\/p>\n

\"\"

Elimination step to form an oxime. Click for animation of reaction mode.<\/p><\/div>\n

    \n
  1. Overall, the transition state<\/a> for this second stage is 12.1 kcal\/mol higher in free energy than the addition step described previously, and some 30 kcal\/mol starting from the tetrahedral intermediate. Unlike the first step, where neutral water could participate in a reaction with a low barrier, here neutral water does not do the trick. To reduce the barrier, one probably needs to add e.g.<\/em> an acid, say HCl to the components. Knowing precisely where to place such an acid is non trivial – I will not reveal an answer now, but will reserve it for a future post.\"\"<\/li>\n
  2. It is worth observing the features (best seen in the gradient norm plot below) in the \u00a0IRC. The small feature at \u00a0IRC -9 \u00a0corresponds to rotation of the \u00a0C-OH group away from an anomeric conformation to prepare it for accepting a proton.<\/li>\n
  3. By IRC -2 (i.e.<\/em> before the actual transition state is reached), the first proton transfer is well under way from the C-OH group to the first water molecule. The cleavage of the C-OH bond is also starting.<\/li>\n
  4. At the transition state (IRC =0.0), this first transfer is almost complete and the second between the two water molecules is starting. The cleavage of the \u00a0C-OH bond is largely complete.<\/li>\n
  5. By IRC +3, \u00a0this second transfer is largely complete and a third from the N-H to the second water is underway.<\/li>\n
  6. By IRC +5, the proton transfers are all finished, and the C=N double bond of the oxime is also largely formed.
    \"\"<\/li>\n<\/ol>\n

    Well, this particular sequence of events is clearly not the full (or even a partial) answer to the mechanism of the second elimination step for this reaction. We know this because it predicts far too large a barrier. Something is missing from this model, and that something is probably a polarizing group such as HCl. Watch this space.<\/p>\n\n<\/div> ","protected":false},"excerpt":{"rendered":"

    This is the follow-up to the previous post exploring a typical nucleophilic addition-elimination reaction. Here is the elimination step, which as before requires proton transfers. We again adopt a cyclic mechanism to try to avoid the build up of charge separation during those proton movements. Overall, the transition state for this second stage is 12.1 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"activitypub_content_warning":"","activitypub_content_visibility":"","activitypub_max_image_attachments":5,"activitypub_interaction_policy_quote":"anyone","activitypub_status":"","footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[],"tags":[843,373],"ppma_author":[2661],"class_list":["post-7822","post","type-post","status-publish","format-standard","hentry","tag-reaction-mechanism","tag-tutorial-material"],"yoast_head":"\nOxime formation from hydroxylamine and ketone. Part 2: Elimination. - Henry Rzepa's Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/?p=7822\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Oxime formation from hydroxylamine and ketone. Part 2: Elimination. - Henry Rzepa's Blog\" \/>\n<meta property=\"og:description\" content=\"This is the follow-up to the previous post exploring a typical nucleophilic addition-elimination reaction. Here is the elimination step, which as before requires proton transfers. We again adopt a cyclic mechanism to try to avoid the build up of charge separation during those proton movements. Overall, the transition state for this second stage is 12.1 […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/?p=7822\" \/>\n<meta property=\"og:site_name\" content=\"Henry Rzepa's Blog\" \/>\n<meta property=\"article:published_time\" content=\"2012-09-25T14:34:13+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2013-01-04T06:48:32+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/www.ch.imperial.ac.uk\/rzepa\/blog\/wp-content\/uploads\/2012\/09\/hydroxylamine2.svg\" \/>\n<meta name=\"author\" content=\"Henry Rzepa\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Henry Rzepa\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Oxime formation from hydroxylamine and ketone. 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Some of the most ancient (i.e. 19th century) known reactions can be considered part of a chemical mythology; perhaps it is time for\u00a0a Janus-like look into their future.\u2026","rel":"","context":"In "Interesting chemistry"","block_context":{"text":"Interesting chemistry","link":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/?cat=4"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.ch.ic.ac.uk\/rzepa\/blog\/wp-content\/uploads\/2010\/12\/diazonium.jpg?resize=350%2C200","width":350,"height":200},"classes":[]},{"id":4837,"url":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/?p=4837","url_meta":{"origin":7822,"position":3},"title":"Anatomy of a simple reaction: the hydration of an alkene.","author":"Henry Rzepa","date":"September 4, 2011","format":false,"excerpt":"The hydration of an alkene by an acid is one of those fundamental reactions, taught early on in most chemistry courses. What can quantum mechanics teach us about the mechanism of the reaction? 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