{"id":5888,"date":"2011-12-13T14:10:34","date_gmt":"2011-12-13T14:10:34","guid":{"rendered":"http:\/\/www.ch.imperial.ac.uk\/rzepa\/blog\/?p=5888"},"modified":"2011-12-16T08:20:43","modified_gmt":"2011-12-16T08:20:43","slug":"mechanistic-morphemes-perisolvolysis-of-a-cyclopropyl-chloride","status":"publish","type":"post","link":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/?p=5888","title":{"rendered":"Mechanistic morphemes. Perisolvolysis of a cyclopropyl chloride."},"content":{"rendered":"
\n

There are many treasures in Woodward and Hoffmann’s (WH)\u00a0classic monograph<\/a>. One such is acetolysis of \u00a0the endo<\/em> chloride (green), which is much much faster<\/a> than that of the exo<\/em> isomer (red). The explanation given in their article (p 805) confines itself to succinctly stating that only loss of the endo<\/em> halogen can be concerted with a required disrotatory ring opening of the cyclopropane. Demonstrating the truth of this statement by computational modelling turns out to be an interesting challenge.<\/p>\n

\"\"<\/a><\/p>\n

I should start by saying that back in 1970, modelling this process quantitatively using extended H\u00fcckel Theory (used by Hoffmann to quantify the orbital behaviours) was not an option. It involves the formation of an ion pair from an initial covalent reactant, and then studying the dynamics of whether or not this formation is concerted with the pericyclic ring opening. These two mechanisms may or may not be conflatable (SN<\/sub>1 + electrocyclic<\/em>). A lot is going on, and it is only very recently that quantum mechanical procedures for combining two such different electronic processes on an equal footing have become available. I did this by using a \u03c9B97XD\/6-311G(d,p) method combined with two explicit solvent molecules for the ion-pair, augmented with a continuum solvent field (in this case ethanoic acid).<\/p>\n

The characteristics of the reaction coordinate<\/a> (IRC) for the endo<\/em> isomer are shown below, followed by an animation of the geometries.<\/p>\n\n\n\n\n
\"\"<\/a><\/td>\n\"\"<\/a><\/td>\n<\/tr>\n
\"\"

Animation of the reaction coordinate for the endo isomer. Click for 3D<\/p><\/div><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    \n
  1. Firstly, the barrier. The reported rate constant corresponds to \u0394G\u2020<\/sup>398<\/sub> 34.4 kcal\/mol. The calculated<\/a> value (from cyclopropyl reactant<\/a>) is ~27.3 kcal\/mol.<\/li>\n
  2. The IRC shows the ring opening and the departure of the chloride are a synchronous concerted process, involving no intermediates. This indeed is a portmanteau<\/a> mechanism, as clearly described by WH.<\/li>\n
  3. Notice how the unconstrained cis<\/em>-hydrogens at the cyclopropyl ring junction can splay out (starting at IRC ~0.0), enabling the resulting cationic centre (the anion is of course the chloride) to adopt a planar configuration with strong \u03c0-conjugation enabled.<\/li>\n
  4. At about IRC = -7, the potential (and its first derivative in the form of the gradient norm) flattens out. This reminds of what happened with the SN<\/sub>1 solvolysis of t-butyl chloride<\/a>. However it does not quite go to zero. There is still the dynamic momentum for one more feature.<\/li>\n
  5. After the allyl “cation” has sorted itself out, the chloride anion returns to the fray, recombining (IRC ~-18) with the cation to replace the ion-pair with a covalent bond. This too is what happened with t-butyl chloride.<\/li>\n<\/ol>\n

    What about the exo<\/em> isomer (red above)? The absence of detectable reaction implies the experimental free energy barrier must be \u2265 40 kcal\/mol. Cleavage of the C-Cl bond is effectively orthogonal with the electrocyclic opening of the C-C cyclopropyl ring, which forces the two mechanisms to occur separately. The first process is an SN<\/sub>1 ionisation of the halide to form the trans<\/em> ion-pair below, which has a free energy<\/a> of 34.9 kcal\/mol relative to the reactant, which is then followed by electrocyclic ring opening as a separate step. This would make a lower bound to its calculated reaction rate at least 10 million times slower than the endo<\/em> isomer. You can see from the coordinates below that the allyl cation cannot become co-planar, which explains its high energy (formation of trans<\/em> cycloalkenes is known to occur<\/a> by such a reaction).<\/p>\n

    \"\"

    Ion-pair formed from exo cyclopropyl halide. Click for 3D.<\/p><\/div>So we have here two quite different reactions. The first is an example of a mechanistic morpheme, a solvolytically assisted pericyclic reaction. It combines two different mechanisms from different areas of organic chemistry (areas which are most often taught as separate lecture courses, and where the holistic connection between the two is rarely made). The second keeps the two reactions quite separate and sequential. All because of an apparently innocent difference in their stereo chemistries.<\/p>\n

    \n

    Henry Rzepa. URL:http:\/\/www.ch.imperial.ac.uk\/rzepa\/blog\/?p=5888. Accessed: 2011-12-16. (Archived by WebCite\u00ae at http:\/\/www.webcitation.org\/63yAww6SH<\/a>)<\/p>\n

    \n\n<\/div> ","protected":false},"excerpt":{"rendered":"

    There are many treasures in Woodward and Hoffmann’s (WH)\u00a0classic monograph. One such is acetolysis of \u00a0the endo chloride (green), which is much much faster than that of the exo isomer (red). The explanation given in their article (p 805) confines itself to succinctly stating that only loss of the endo halogen can be concerted with […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"activitypub_content_warning":"","activitypub_content_visibility":"","activitypub_max_image_attachments":5,"activitypub_interaction_policy_quote":"anyone","activitypub_status":"","footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[4],"tags":[2650,792,373],"ppma_author":[2661],"class_list":["post-5888","post","type-post","status-publish","format-standard","hentry","category-interesting-chemistry","tag-pericyclic","tag-solvolysis","tag-tutorial-material"],"yoast_head":"\nMechanistic morphemes. Perisolvolysis of a cyclopropyl chloride. - Henry Rzepa's Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/?p=5888\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mechanistic morphemes. Perisolvolysis of a cyclopropyl chloride. - Henry Rzepa's Blog\" \/>\n<meta property=\"og:description\" content=\"There are many treasures in Woodward and Hoffmann’s (WH)\u00a0classic monograph. One such is acetolysis of \u00a0the endo chloride (green), which is much much faster than that of the exo isomer (red). The explanation given in their article (p 805) confines itself to succinctly stating that only loss of the endo halogen can be concerted with […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/?p=5888\" \/>\n<meta property=\"og:site_name\" content=\"Henry Rzepa's Blog\" \/>\n<meta property=\"article:published_time\" content=\"2011-12-13T14:10:34+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2011-12-16T08:20:43+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/www.ch.imperial.ac.uk\/rzepa\/blog\/wp-content\/uploads\/2011\/12\/cp.svg\" \/>\n<meta name=\"author\" content=\"Henry Rzepa\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Henry Rzepa\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Mechanistic morphemes. 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A computational mechanism revealed that AlCl3 or its dimer Al2Cl6 could catalyse a concerted 1,1-substitution reaction at the carbon of Cl-C\u2261N, with benzene displacing chloride which is in turn captured by the Al. Unfortunately the calculated barrier for this simple process was\u2026","rel":"","context":"In "reaction mechanism"","block_context":{"text":"reaction mechanism","link":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/?cat=1086"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.ch.ic.ac.uk\/rzepa\/blog\/wp-content\/uploads\/2020\/12\/CNAl-1024x889.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":21616,"url":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/?p=21616","url_meta":{"origin":5888,"position":2},"title":"Molecules of the year – 2019: the incredible chloride cage.","author":"Henry Rzepa","date":"December 13, 2019","format":false,"excerpt":"Each year, C&E News runs a poll for their \"Molecule of the year\". 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The mechanism of this transformation as shown in e.g. Wikipedia is illustrated below.\u2021 However, an interesting and important aspect of chemistry is not apparent in this schematic mechanism\u2026","rel":"","context":"In "Curly arrows"","block_context":{"text":"Curly arrows","link":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/?cat=2327"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":439,"url":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/?p=439","url_meta":{"origin":5888,"position":5},"title":"The mystery of the Finkelstein reaction","author":"Henry Rzepa","date":"May 16, 2009","format":false,"excerpt":"This story starts with an organic chemistry tutorial, when a student asked for clarification of the \u00a0Finkelstein reaction. This is a simple SN2 type displacement of an alkyl chloride or bromide, using sodium iodide in acetone solution, and resulting in an alkyl iodide. What was the driving force for this\u2026","rel":"","context":"In "Interesting chemistry"","block_context":{"text":"Interesting chemistry","link":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/?cat=4"},"img":{"alt_text":"(Acetone)3. 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