{"id":17763,"date":"2017-03-19T14:10:12","date_gmt":"2017-03-19T14:10:12","guid":{"rendered":"http:\/\/www.ch.imperial.ac.uk\/rzepa\/blog\/?p=17763"},"modified":"2017-03-20T17:05:36","modified_gmt":"2017-03-20T17:05:36","slug":"peroxydisulfate-enables-a-non-enzymatic-krebs-cycle-precursor","status":"publish","type":"post","link":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/?p=17763","title":{"rendered":"Peroxydisulfate – “enables a non-enzymatic Krebs cycle precursor”"},"content":{"rendered":"
\n

The Wikipedia entry on peroxydisulfate<\/a> is quite short (as of today). But I suspect this article may change things.[1]<\/a><\/span>.<\/p>\n

\"\"<\/a><\/p>\n

A search of the Cambridge structure database reveals around 18 high quality crystal structures containing this species are known, many as metal salts.<\/p>\n

\"\"<\/p>\n

The article[1]<\/a><\/span> reports that “in the presence of sulfate radicals generated from peroxydisulfate<\/em>,\u00a0the (<\/em>Krebs cycle) intermediates underwent 24 interconversion reactions<\/em>” covering “the critical topology of the oxidative Krebs cycle, the glyoxylate shunt and the succinic-semialdehyde pathway<\/em>“. The suggestion therefore is that these crucial metabolic \u00a0reactions may have existed before life itself absorbed them into the oxidative Krebs cycle<\/a>. The challenge now<\/a> is to explain how or if the more ancient\u00a0reductive Krebs cycle<\/a>\u00a0(which fixes carbon dioxide<\/a>) might have arisen prebiotically. More exciting stuff to come I fancy.<\/p>\n

References<\/h2>\n
  1. M.A. Keller, D. Kampjut, S.A. Harrison, and M. Ralser, \"Sulfate radicals enable a non-enzymatic Krebs cycle precursor\", Nature Ecology & Evolution<\/i>, vol. 1, 2017. https:\/\/doi.org\/10.1038\/s41559-017-0083<\/a>\n\n<\/li>\n<\/ol>\n\n<\/div> ","protected":false},"excerpt":{"rendered":"

    The Wikipedia entry on peroxydisulfate is quite short (as of today). But I suspect this article may change things.. A search of the Cambridge structure database reveals around 18 high quality crystal structures containing this species are known, many as metal salts. The article reports that “in the presence of sulfate radicals generated from peroxydisulfate,\u00a0the […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":true,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"activitypub_content_warning":"","activitypub_content_visibility":"","activitypub_max_image_attachments":5,"activitypub_interaction_policy_quote":"anyone","activitypub_status":"","footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1745,4],"tags":[2075,2074],"ppma_author":[2661],"class_list":["post-17763","post","type-post","status-publish","format-standard","hentry","category-crystal_structure_mining","category-interesting-chemistry","tag-metal-salts","tag-peroxydisulfate"],"yoast_head":"\nPeroxydisulfate - "enables a non-enzymatic Krebs cycle precursor" - Henry Rzepa's Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/?p=17763\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Peroxydisulfate - "enables a non-enzymatic Krebs cycle precursor" - Henry Rzepa's Blog\" \/>\n<meta property=\"og:description\" content=\"The Wikipedia entry on peroxydisulfate is quite short (as of today). 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This contrasts with traditional lenses that are not flat and where the optical properties result from very accurately engineered curvatures, which\u2026","rel":"","context":"In "Interesting chemistry"","block_context":{"text":"Interesting chemistry","link":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/?cat=4"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":11681,"url":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/?p=11681","url_meta":{"origin":17763,"position":5},"title":"Caesium trifluoride: could it be made?","author":"Henry Rzepa","date":"November 23, 2013","format":false,"excerpt":"Mercury (IV) tetrafluoride attracted much interest when it was reported in 2007 as the first instance of the metal being induced to act as a proper transition element (utilising d-electrons for bonding) rather than a post-transition main group metal (utilising just s-electrons) for which the HgF2 dihalide would be more\u2026","rel":"","context":"In "Hypervalency"","block_context":{"text":"Hypervalency","link":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/?cat=7"},"img":{"alt_text":"Click for 3D","src":"https:\/\/i0.wp.com\/www.ch.imperial.ac.uk\/rzepa\/blog\/wp-content\/uploads\/2013\/11\/CsF31.jpg?resize=350%2C200","width":350,"height":200},"classes":[]}],"jetpack_likes_enabled":false,"authors":[{"term_id":2661,"user_id":1,"is_guest":0,"slug":"admin","display_name":"Henry Rzepa","avatar_url":"https:\/\/secure.gravatar.com\/avatar\/897b6740f7f599bca7942cdf7d7914af5988937ae0e3869ab09aebb87f26a731?s=96&d=blank&r=g","0":null,"1":"","2":"","3":"","4":"","5":"","6":"","7":"","8":""}],"_links":{"self":[{"href":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/index.php?rest_route=\/wp\/v2\/posts\/17763","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17763"}],"version-history":[{"count":4,"href":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/index.php?rest_route=\/wp\/v2\/posts\/17763\/revisions"}],"predecessor-version":[{"id":17769,"href":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/index.php?rest_route=\/wp\/v2\/posts\/17763\/revisions\/17769"}],"wp:attachment":[{"href":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17763"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17763"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17763"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.ch.ic.ac.uk\/rzepa\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fppma_author&post=17763"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}