Thomas Yue

Contact

thomas.yue15@imperial.ac.uk

Research

“Development of Novel Bifunctional Chelates for the Creation of Site-Specifically Modified Radioimmunoconjugates”

ImmunoPET combines the extraordinary specificity of monoclonal antibodies with the superior sensitivity of positron emission tomography, offering a non-invasive solution to assess target receptors’ expression and distribution in vivo. However, conventional strategies for antibody-radionuclide conjugation such as lysine- and cysteine-based conjugations generate heterogenous mixtures of antibody-conjugates which can exhibit suboptimal pharmacokinetics and decreased affinity for target receptors. This project therefore seeks to circumvent these issues by developing novel bifunctional chelates targeting low abundance canonical amino acids for radiolabelling with 89Zr and 68Ga, with the aim of their translation into facile formulations for site-specific radiolabelling of antibodies and their derivatives.

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