Shane Angoh

Contact


shane.angoh13@ic.ac.uk

Research


Smart Manganese-based Dual-modal PET-MRI Probes

The combination of magnetic resonance imaging (MRI) – with its excellent spatial, sub-millimetre resolution – and positron emission tomography (PET) – with its exceptionally high sensitivity – would be able to provide greater clinical functionality through ‘PET-guided’ high resolution MRI. The challenge in creating a bimodal PET/MRI agent comes from the sensitivity difference in these techniques. Manganese based contrast agents (MnBCA) can overcome these issues by mixing nanomolar amounts of radionuclide with 55Mn in complexation, thus creating a chemically identical PET and MRI probe, ensuring identical biodistribution and pharmacokinetic behaviour.

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