References

1. Seghal et al.; J.Antibiot.; 28; 1975; 727,729;

2. J. B. McAlpine, S. J. Swanson, M. Jackson, D. N. Whittern; J.Antibiot.; 44; 1991; 688-690;

3. K. C. Nicolaou, T. K. Chakraborty, A. D. Piscopio, N. Minowa, P. Bertinato; J. Am. Chem. Soc.; 115; 1993; 4419

4. C. M. Hayward, D. Yohannes, S. J. Danishefsky; J. Am. Chem. Soc.; 115; 1993; 9345

5. S. D. Meyer, T. Miwa, M. Nakatsuka, S. L. Schreiber; J. Org. Chem.; 57; 1992; 5058-5060

6. D. Romo, D. D. Johnson, L. Plamondon, T. Miwa, S. L. Schreiber; J. Org. Chem.; 57; 1992; 5060-5063

7. S. D. Meyer, D. Romo, D. D. Johnson, S. L. Schreiber; J. Am. Chem. Soc.; 115; 1993; 7906-7907

8. S. L. Schreiber et al; Acc. Chem. Res.; 26; 8; 1993; 413

9. T. B. Strom, L. A. Turka et al; Nature Medicine; 5; 11; 1999; 1298-1302

10. T. B. Strom, A. D. Wells et al; Nature Medicine; 5; 11; 1999; 1303-1307

11. R. Sedrani et al; Bioorg. & Med. Chem. Lett.; 9; 1999; 459-462

12. G. D. Van Duyne, R. F. Standaert, S. L. Schreiber, J. Clardy; J. Am. Chem. Soc.; 113; 1991; 7433-7434

Useful websites:

• http://www.ahp.com
• http://www-schreiber.chem.harvard.edu/home/research.html
• http://www.hhmi.org
• http://dtp.nci.nih.gov/docs/static_pages/compounds/226080.html (rotating molecule on title page)
• http://www.astp.org

Review of information sources

Internet Search engines:

Yahoo, Hotbot, Netscape search - searches on 'rapamycin, transplants, cancer, T cells'. The netscape (Google) searches were the most successful.

Chemical information services:

BIDS - A bit slow to use and slightly unreliable, wouldn't always let me log on and once directed me to WOS as it was too busy.

WOS - advanced search very good - gave large number of hits. 'Marked list' facility difficult to use, seemed to lose marked entries very easily.

Beilstein - searched using chemical name and molecular weight. Good source of data and journal references on physical properties and spectral data.

Chemfinder- gave only structure and formula of rapamycin, no physical data was available.

Brookhaven protein data bank- easy to use, found 3D structure of binding proteins just using 'rapamycin' as search term.  

NCI database - found 3D coordinates of rapamycin molecule as well as cancer activity information.