Website sources:

Pfizer US Webpage     http://www.pfizer.com/hml/pi's/diflucanpi.html
Aids drugs database     http://www.actis.org
Diflucan story               http://www.oldkingdom.org/
3-D structure                http://triton.ps.toyaku.ac.jp/~dobashi/database/structure/f_group/fluconazole.html
AIDS support               http://www.aidsinfonet.org/534e-fluconazole.html

All of the above websites were found using the Google, AltaVista and Mamma search engines.  Whilst it was not possible to find chemically related information such as synthetic techniques, or detailed descriptions of drug action from websites, vast information of the pharmacokinetics, adverse reactions, alternatives and usage of fluconazole as well as the political situation of South Africa in particular was available.  I found that most sites however were repeating the same information as their principle source of information was the US Pfizers website.

Literature sources:

1. Fromtling RA. Overview of medically important antifungal azole derivatives. Clinical Microbiology Reviews 1988; 1: 187-217.

2. X.J. Gu and W.Jiang, Characterisation of polymorphic forms of fluconazole us FT-IR and Raman Spectroscopy, Journal of Pharmaceutical Sciences 12,1995;1438-1441

3. A.Narayanan et al, Conversion of 4-amino-4H-1,2,4-triazole to 1,3-Bis(1 H-azol-1-yl)-2-aryl-2-propanols, J Heterocyclic Chem, 30,(1993) 1405-1410

4. T.D. Cyr et al, Spectral characterisation of fluconazole, J Pharm and Bio Sci, 14, (1996) :247-255

5. Murthy et al. Methods for the manufacture of fluconazole: patent number 5508423 (1995)

6. Clive et al. Commercial process for the manufacture of fluconazole and intermediates useful in the manufacture thereof: patent number 5872258 (1998)

The journal articles above were found by a combination of using the Beilstein Crossfire database, the Web Of Science system and a US patent search engine located at http://www.uptso.gov . They were the principal source of data available for synthesis methods and physical data.

Chemical Information Sources:

Brookhaven Protein Structure Database: Used to obtain the complex 3-D images of cytochrome P450.