Bibliography

Website sources:

http://www.templejc.edu/ems/drugs/Albuterol.htm
http://onhealth.webmd.com/conditions/resource/pharmacy/
http://128.242.211.97/healthnotes/Drug/Albuterol.cfm?
http://asthma.about.com/health/asthma/library/weekly/aa053199.htm
http://www.rxlist.com/cgi/generic/albut1.htm
http://www.combivent.com/cbpi.html
http://www.kcmetro.cc.mo.us/pennvalley/emt/albut.htm
http://micro.magnet.fsu.edu/pharmaceuticals/pages/albuterol.html
http://www.cheshire-med.com/programs/pulrehab/asthma/a3beta.html
http://www.glaxowellcome.com/pi/ventinh.pdf
http://www.mapoison.org/ctr/9511albuterol.html
http://www.chemistry.vt.edu/chem-dept/helm/2514/project/albuterol/albuterol.html
http://www.chem.ox.ac.uk/course/ityearone/week10/albuterol.htm
http://www.nephronpharm.com/pages/documents/albuterol.pdf
http://www.chemistry.vt.edu/chem-dept/helm/2514/project00/albuterol/albuterol.html
http://www.chestnet.org/publications/Pulmonary.Perspectives/vol16n4b.html
http://www.imc.gsm.com

All of the above websites were found using the Google search engine. A number of other search engines such as AltaVista and Yahoo were also used, but the results they all came up with were duplicates of those obtained from Google. Whilst it was not possible to find chemically related information such as synthetic techniques, or detailed descriptions of drug action from websites, much information of the pharmacokinetics, adverse reactions, alternatives and usage of salbutamol was yielded.

Literature sources:

H.P. Rang & M.M. Dale, Pharmacology, 2nd Edition, 1991, Churchill Livingstone
B.G. Katzung, Basic & Clinical Pharmacology, 6th Edition, 1995, Appleton & Lagrange

Hong, Gai, Nie and Zepp, Tetrahedron Letters, 1994, 35, pp 5551-5554
Babad, Carruthers, Jaret and Steinman, Synthesis, 1988, pp 966-968
Regla, Reyes, Korber, Demare, Estrada and Juari, Synthetic Communications, 1997, 5, 817-823
Collin, Hartley, Jack, Lunts, Press, Ritchie and Toon, Journal of Medicinal Chemistry, 1970, 13, 674

The journal articles above were found by a combination of using the Beilstein Crossfire database and the Web Of Science system. They were the only source of data available such as synthesis methods and NMR data. Beilstein Crossfire was also useful in providing some physical data.

Chemical Information Sources:

Brookhaven Protein Structure Database: Used to obtain the complex 3-D images of a beta₂ receptor and adenylyl cyclase.
CORINA: This was the source of the 3D image of salbutamol used in this project. The CORINA program converts a 1-D SMILES string into a set of 3-D co-ordinates that can be used by the Chime plug-in to display a 3-D image of a molecule.
Telespec: This website was used to simulate the infra-red spectrum of salbutamol and salbutamol sulphate.
Chemfinder: This system was used to find every 2-D diagram of molecular structures used in this project. The website also contained links to further information regarding the molecules. From these images it is easy to generate SMILES code and thus a 3-D structure.