L . E . D . S . S .

alpha-Methylamino-benzo[b][1,7]phenanthroline-methanol:a DNA Intercalating Drug with Alkylating Properties

E. Charrel, N. Fixler, M.Demeunynck, J.Michon, P.Vatton, J.Lhomme

LEDSS Université J. Fourier, BP 53, 38041 Grenoble cedex, FRANCE

Reactivity studies

1- Heterolytic reactions: Quinone-imine-methide intermediate as a highly electrophilic species

2- Homolytic reactions: Photochemical degradation

3- Reactivity on DNA: covalent binding of the drug to the macromolecule

General Conclusion

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