Dynamic control of topological asymmetry:
Ligand synthesis

The modeled ligands were synthesized in the racemic and enantiomerically pure forms [1], as shown in the schemes below. Enantiomerically pure ligands were prepared by classical resolution of the racemic mixture of the corresponding amine. A list of the full chemical names for the ligands is available.

Scheme 1 [2]
Synthesis of a-MeTPA
[Scheme of synthesis of the MeTPA   ligand]

Scheme 2 [3]
Synthesis of a-PhTPA
[Scheme of synthesis of the PhTPA   ligand]

Scheme 3 [2]
Synthesis of a-MeBQPA
[Scheme of synthesis of the MeBQPA   ligand]

  1. Except in the case of the a-PhTPA ligand, for which only the racemic form was prepared.
  2. Canary, J.W.; Allen, C.S.; Castagnetto, J.M.; Wang, Y. J. Am. Chem. Soc. 1995, 117, 8484.
  3. Canary, J.W.; Allen, C.S.; Castagnetto, J.M.; Wang, Y.; Xu, X., manuscript in preparation.

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