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Review of sources used for this project:
Beilstein: This was very useful for the reactions of Relenza and physical properties as well as being easy to use. It did not contain the CAS registry number for the drug (which had to be found using internet search engines). There were a number of useful references here.
ChemDraw: Again, this was simple to use and easily converted into a SMILES string so that a three-dimensional version of Relenza could be seen. This was not included in this web-page as it would have slowed it down and the PDB or mol file it is saved as is not supported by all browsers.
Web of Science: Gave lots of information on clinical studies as well as supplying a few useful journals.
Electronic Journals: Between ScienceDirect, RSClectronic Journals, JACs electronic journals and the Imperial College Catalogue most of the journals were covered. Another useful site is http://www.ansto.gov.au/info/library/libjournal/fulljrn.htm which also covers a large range of journals. Unfortunately the journals normally do not date back more than 4 or 5 years, and some do less than this. It was also slow to use and frustrating when you couldn't always select text or pictures.
Daylight: This programe recognised my SMILES string as a valid one, but did not have a record of Relenza on its databases and so was not much use.
NIST Chem Web book: Although this is probably an extremely useful website normally, it failed to recognise the molecular weight, formula, or any of the chemical names of my compound. Although I found a CAS number for Relenza via a search engine, I'm not completely sure that it was a valid one.
BL OPAC: The information found was slightly limited and did not go into enough chemical depth.
Chemfinder: As in the case of the NIST Chem Web book this failed to recognize chemical names, formula, weight or CAS number.
|Key Search words:
Relenza, zanamivir, 4-Guanidino-Neu5Ac2en, 5- Acetamido- 2, 6- anhydro- 3, 4, 5- trideoxy- 4- guanidino- D- glycero- D- galacto- non- 2- enonic acid (unsuccessful), and 2,3- Didehydro- 2, 4- dideoxy- 4- guanidino- N- acetyl- D- neuraminic acid were all tried individually and also with NMR, IR, nuclear magnetic resonance, infrared, three dimensional structure, synthesis, reactions, influenza, neuraminidase, sialidase and 'flu. Most of the information obtained was more related to the immunology than the chemistry, but some useful journals were found. Google was found to be the best search engine for scientific information and metalocate gave a large range of slightly more general stuff.
|Useful web addresses:|
|http://www.biol.unt.edu/~farinha/virology/orthomyx.htm. This describes symptoms of the flu, information on the influenza life cycle and structure of the virus. It also gives information on Rimantidine and amantidine|
|The others have already been included in this web page.|