References and review of information sources
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2. J. B. McAlpine, S. J. Swanson, M. Jackson, D. N. Whittern; J.Antibiot.; 44; 1991; 688-690;
3. K. C. Nicolaou, T. K. Chakraborty, A. D. Piscopio, N. Minowa, P. Bertinato; J. Am. Chem. Soc.; 115; 1993; 4419
4. C. M. Hayward, D. Yohannes, S. J. Danishefsky; J. Am. Chem. Soc.; 115; 1993; 9345
5. S. D. Meyer, T. Miwa, M. Nakatsuka, S. L. Schreiber; J. Org. Chem.; 57; 1992; 5058-5060
6. D. Romo, D. D. Johnson, L. Plamondon, T. Miwa, S. L. Schreiber; J. Org. Chem.; 57; 1992; 5060-5063
7. S. D. Meyer, D. Romo, D. D. Johnson, S. L. Schreiber; J. Am. Chem. Soc.; 115; 1993; 7906-7907
8. S. L. Schreiber et al; Acc. Chem. Res.; 26; 8; 1993; 413
9. T. B. Strom, L. A. Turka et al; Nature Medicine; 5; 11; 1999; 1298-1302
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12. G. D. Van Duyne, R. F. Standaert, S. L. Schreiber, J. Clardy; J. Am. Chem. Soc.; 113; 1991; 7433-7434
Review of information sources
Internet Search engines:
Yahoo, Hotbot, Netscape search - searches on 'rapamycin, transplants, cancer, T cells'. The netscape (Google) searches were the most successful.
Chemical information services:
BIDS - A bit slow to use and slightly unreliable, wouldn't always let me log on and once directed me to WOS as it was too busy.
WOS - advanced search very good - gave large number of hits. 'Marked list' facility difficult to use, seemed to lose marked entries very easily.
Beilstein - searched using chemical name and molecular weight. Good source of data and journal references on physical properties and spectral data.
Chemfinder- gave only structure and formula of rapamycin, no physical data was available.
Brookhaven protein data bank- easy to use, found 3D structure of binding proteins just using 'rapamycin' as search term.
NCI database - found 3D coordinates of rapamycin molecule as well as cancer activity information.