The information to create this project was originally found using various search engines on the internet. There was a great variation in their usefulness, as highlighted below:
 

• Beilstein Commander - This was useful for finding the structure and name of this molecule. A good starting point. A useful reference was also given here.
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• Scifinder Scholar - This was by far the most useful of the search engines. This gave a great number of references many of which proved to invaluable. However, none of these journals were on the internet due to their age, and some were in very obscure journals, which proved to be unobtainable.
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• WOS - This gave a fair number of search results, but a very small number of these were found to be informative
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• BLPC, NIST, PDB, ACS and RSC were all used to search for capreomycin. Unfortunately, none of these had any search results whatsoever, and therefore proved useless in this project.
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• Google - This produced thousands of hits, but having sieved through all of these, only three had any information on them that I needed. Most of the pages found were medical advice sheets. When the search was narrowed down to chemical sites, or only images, nothing was found.
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• gNMR - As mentioned on the Physical Properties page, this could only calculate the ¹H NMR for compounds with less than 23 protons, which does not include capreomycin. Otherwise, this would have been a very useful site for generating NMRs.
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• Corina - This was a very easy program to use for generating the 3D rotating molecule shown on the title page.
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• Chemdraw - This was an invaluable program for creating the structures and syntheses shown. The SMILES string needed for Corina was also generated here.
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• Photosuite MGI - This program was used for the modification of .gif files containing the images used and was invaluable in creating the background to the page.
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• Microsoft Word - This was found to be the most useful program for creating the tables.
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  Overall the search engines were generally very easy to use. However, actually finding useful information on this drug was far more difficult. This may be because capreomycin is not so well known and because most of the research into it has not been done since the publication of journals on the internet.

  References:

  1. An Introduction to Peptide Chemistry - P.D. Bailey
  2. Organic Chemistry - Vollhardt and Schore
  3. Peptide Synthesis - M. Bodanszky, Y. Klausner and M. Ondetti
  4. Pharmacology - H.P. Rand, M.M. Dale and J.M. Ritter
  5. http://www.aidsinfonyc.org/network/access/drugs/capr.html
  6. http://rwingo1.chm.colostate.edu/group/duane/duane.html
  7. http://www.hucmlrc.howard.edu/Pharmacology/handouts/TBRCLSIS.html
  8. J. Org.Chem.,1977, 42, 8 - McGahren, Morton, Kunstmann, Ellestad
  9. Bull.W.H.O., 1972, 47(3), 343-56 - Lightbrown et al.
  10. Tetrahedron, 1978, 34(7), 912-7 - Nomoto, Teshima, Wakamiya, Shiba
  11. Tetrahedron Letters, 1976, 43, 3907-10 - Shiba, Nomoto, Teshima, Wakamiya
  12. J.Org.Chem., 1992, 57, 5214-5217 - Gould and Minott
  13. Tetrahedron Letters, 1969, 30, 2549-41 - Bycroft, Cameron, Hassanali-Walji and Johnson
  14. Bull.Chem.Soc.Jpn, 1979, 52(6), 1709-15 - Nomoto and Shiba
  15. Experimentia - 1976, 32(9), 1109-11 - Nomoto and Wakamiya
  16. Pharmazie - 1970, 25(8), 471-2 - Voigt and Maa Bared
  17. Antimicrobial Agents Chemotherapy, 1964, 522-9 - Black, Griffith and Brickler
  18. Antimicrobial Agents Chemotherapy, 1962, 201-12 - Herr
  19. www2.chemie.uni-erlangen.de/services/telespec