2.5.2.Friedel-Crafts Acylation
product is less reactive than the starting material thus:
also no rearrangements possible because of the reaction mechanism.
use of acid anhydrides in Friedel-Crafts acylation chemistry.
A case study: The Haworth synthesis of naphthalenes.
Directing Effects in Disubstituted Benzenes
R+HX
+R'-COX
+AlCl4
+H+
AlCl3
Clemmensen
Zn/HCl
Clemmensen
Zn/HCl
CH3
NO2
SO3H
NHCOCH3
CN