Objectives: To conduct a literature search on Penicillin
Experiment 2 in this course is based on
the conversion of a penicillin derivative to a cephalosporin,
and its purification using a technique known as Flash Chromatography.
You should in this technique try to find out how to search the litarature
for information about these compounds, their preparation and purification, their chemistry
and their uses.
Planning the Experiment
Overall, you are expected to spend about 1 week on this technique, equivalent
to 4-6 hours of "lab" time. You will find however, that access to some of the
databases might be difficult during the afternoon, when demand hits a peak. Most
of the sources of information will display on a Macintosh computer, but some
(noteably the Cambridge crystallographic search) are best done using a
You will be expected to "capture" the results of some searches either in a
Word Processor (Claris Works), or in the form of disk based computer files,
which might need to be transferred to another computer for further processing.
The "write-up" should be critical, and should contain selected examples of
your search results. It will be assessed on this basis.
You should NOT simply submit an un-edited all-inclusive
list of all that you found.