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Selected Recent Publications, R.J. Leatherbarrow
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This page last updated
11 November, 2003
Brauer, A.B.E. &
Leatherbarrow, R.J. (2003) The conserved P1' Ser of Bowman-Birk-type
proteinase inhibitors is not essential for the integrity of the reactive
site loop. Biochem. Biophys. Res. Commun. 308, 300-305. |
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190KB |
Brauer, A.B.E, Nievo,
M., McBride, J.D. & Leatherbarrow, R.J. (2003) The Structural Basis of a
Conserved P2 Threonine in Canonical Serine Proteinase Inhibitors J.
Biomol. Struct. Dyn. 20, 645-655. |
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1058KB |
Brauer, A.B.E.
Domingo, G.J., Cooke, R.M., Matthews, S. J. & Leatherbarrow, R.J.
(2002) A conserved cis peptide bond is necessary for the activity of
Bowman-Birk inhibitor protein. Biochemistry 41,
10608-10615.
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328KB |
McBride, J.D., Watson,
E.M., Brauer, A.B.E. and Jaulent, A.M. & Leatherbarrow, R.J. (2002)
Peptide Mimics of the Bowman-Birk Inhibitor Reactive Site Loop
Biopolymers 66,
79-92. |
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543KB |
Brauer,
A.B.E., Kelly, G., Matthews, S.J. & Leatherbarrow, R.J. (2002) The 1H-NMR
Solution Structure of the Antitryptic Core Peptide of Bowman-Birk Inhibitor
Proteins: a minimal ‘canonical loop’ J. Biomol Struct. Dyn. 20,
59-70. |
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558KB |
Scarpi, D., McBride, J.D. and Leatherbarrow R.J. (2002) Inhibition of Human b-Tryptase by Bowman-Birk Inhibitor Derived Peptides. J. Pept.
Res. 59, 90-93
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68KB |
Scarpi, D., Occhiato, E.G., Trabocchi, A., Leatherbarrow, R.J.,
Brauer, A.B.E., Nievo, M. and Guarna, A. (2001) Introduction of the
New Dipeptide
Isostere 7-Endo-BtA as Reverse Turn Inducer in a Bowman-Birk Proteinase
Inhibitor:
Synthesis and Conformational Analysis. Bioorg. Med. Chem. 9,
1625-1632
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587KB |
McBride, J.D. & Leatherbarrow, R.J. (2001) Synthetic peptide mimics of the
Bowman-Birk inhibitor protein. Curr. Med. Chem. 8, 909-917.
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100KB |
Brauer, A.B.E. , Kelly, G., McBride, J.D., Cooke, R.M., Matthews, S.J. &
Leatherbarrow, R.J. (2001) The Bowman-Birk Inhibitor Reactive Site Loop Sequence
Represents an Independent Structural b-Hairpin Motif. J.
Mol. Biol. 306, 799-807.
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301KB |
McBride, J.D, Freeman, H.N., Watson, E.M. & Leatherbarrow, R.J. (2000) Chymotrypsin
Inhibitors Identified from a Second-Generation Template Assisted Combinatorial Peptide
Library Proceedings of the 6th International Symposium on Solid Phase Synthesis and
Combinatorial Chemical Libraries 1999 (Epton, R., ed) Mayflower Scientific press (in
the press)
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21KB |
McBride, J.D., Freeman, H.N. & Leatherbarrow, R.J. (2000) Identification of
Chymotrypsin Inhibitors from a Second-Generation Template Assisted Combinatorial Peptide
Library. J. Pept. Sci. 6, 446-452.
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89KB |
Leatherbarrow, R.J. & Edwards, P.R. (1999) Analysis of Molecular Recognition using
Optical Biosensors Current Opinion in Chemical Biology 3, 544-547.
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212KB |
McBride, J.D., Freeman, H.N.M. & Leatherbarrow, R.J. (1999) Selection of Human
Elastase Inhibitors from a Conformationally-Constrained Combinatorial Peptide Library. Eur.
J. Biochem. 266, 403-412.
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422KB |
Gariani, T. McBride, J.D. & Leatherbarrow, R.J. (1999) The role of the P2
residue of Bowman-Birk inhibitors. Studies on P2 variation in cyclic
peptides encompassing the reactive site loop. Biochim. Biophys. Acta. 1431,
232-237.
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167KB |
McBride, J.D., Freeman, N. & Leatherbarrow, R.J. (1999) Selection of human elastase
inhibitors from a conformationally-constrained combinatorial peptide library. Innovations
and perspectives in solid phase synthesis and combinatorial libraries 1998 (Epton, R.,
ed) Mayflower Scientific press pp167-172.
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484KB |
McBride, J.D., Brauer, A.B.E., Nievo, M. & Leatherbarrow, R.J. (1999) Functional
requirement for a threonine in the P2 position of a cyclic peptide mimetic of a
Bowman-Birk proteinase inhibitor. Innovations and perspectives in solid phase synthesis
and combinatorial libraries 1998 (Epton, R., ed) Mayflower Scientific press pp341-344.
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255KB |
McBride, J.D., Nievo, M., Brauer, A.B.E. & Leatherbarrow, R.J. (1998) The Role of
Threonine in the P2 Position of Bowman-Birk Proteinase Inhibitors. Studies on P2
Variation in Cyclic Peptides Encompassing the Reactive Site Loop. J.Mol. Biol. 282,
447-458.
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596KB |
Edwards, P.R. Maule, C.H. Leatherbarrow, R.J. and Winzor, D.J. (1998) Second-order
kinetic analysis of IAsys biosensor data: Its use and applicability. Anal. Biochem.
263, 1-12.
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233KB |
Hasan, Z. & Leatherbarrow, R.J. (1998) A Study of the Specificity of Barley
Chymotrypsin Inhibitor 2 by Cysteine Engineering of the P1 Residue. Biochim. Biophys.
Acta. 1384, 325-334.
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115KB |
Foord, R.L. & Leatherbarrow, R.J. (1998) Effect of Osmolytes on the Exchange Rates
of Backbone Amide Protons in Proteins. Biochemistry 37, 2969-2978.
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132KB |
Hasan, Z. & Leatherbarrow, R.J. (1997) Introduction of Trypsin Specificity into
Chymotrypsin Inhibitor II. Prot. Pept. Lett. 4, 335-342.
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595KB |
Edwards, P.R. & Leatherbarrow, R.J. (1997) Determination of Association Rate
Constants by an Optical Biosensor using Initial Rate Analysis. Anal. Biochem.
(1997) 246, 1-6.
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126KB |
Gariani, T. and Leatherbarrow, R.J. (1997) Stability of protease inhibitors based on the
Bowman-Birk reactive site loop to hydrolysis by proteases. J Peptide Res. 49,
467-475.
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673KB |
Edwards, P.R., Lowe, P.A. & Leatherbarrow, R.J. (1997) Effect of surface loading
upon the kinetics of protein-protein interactions as monitored by an optical biosensor. Journal
of Molecular Recognition 10, 128-134.
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227KB |
McBride, J.D., Harbeck, B. and Leatherbarrow, R.J. (1996) Resin coupled peptides as
proteinase inhibitors. Prot. Pept. Lett. 3, 193-198.
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423KB |
McBride, J.D., Freeman, N., Domingo, G.J. and Leatherbarrow, R.J. (1996) Selection of
chymotrypsin inhibitors from a conformationally-constrained combinatorial library. J.
Mol. Biol. 259, 819-827.
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557KB |
Edwards, P.R., Gill, A., Pollard-Knight, D.V., Leatherbarrow, R.J., Hoare, M. &
Yeung, D. (1995) Kinetics of bimolecular complex formation at the surface of an optical
biosensor. Anal. Biochem. 231, 210-217.
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1,076KB |
Domingo, G.J., Leatherbarrow, R.J., Freeman, N., Patel, S. & Weir, M. (1995)
Synthesis of a mixture of cyclic peptides based on the Bowman-Birk reactive site loop to
screen for serine protease inhibitors. Int. J. Peptide Protein Res. 46,
79-87.
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1,301KB |
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