Research Sample
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Selected Recent Publications, R.J. Leatherbarrow

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For a more informal example of some of the things we do, see the research sample pages

This page last updated 11 November, 2003

Brauer, A.B.E. & Leatherbarrow, R.J. (2003) The conserved P1' Ser of Bowman-Birk-type proteinase inhibitors is not essential for the integrity of the reactive site loop. Biochem. Biophys. Res. Commun. 308, 300-305. 190KB
Brauer, A.B.E, Nievo, M., McBride, J.D. & Leatherbarrow, R.J. (2003) The Structural Basis of a Conserved P2 Threonine in Canonical Serine Proteinase Inhibitors J. Biomol. Struct. Dyn. 20, 645-655. 1058KB
Brauer, A.B.E. Domingo, G.J., Cooke, R.M., Matthews, S. J. & Leatherbarrow, R.J. (2002) A conserved cis peptide bond is necessary for the activity of Bowman-Birk inhibitor protein. Biochemistry 41, 10608-10615.       328KB
McBride, J.D., Watson, E.M., Brauer, A.B.E. and Jaulent, A.M. & Leatherbarrow, R.J. (2002) Peptide Mimics of the Bowman-Birk Inhibitor Reactive Site Loop Biopolymers 66, 79-92. 543KB
 Brauer, A.B.E., Kelly, G., Matthews, S.J. & Leatherbarrow, R.J. (2002) The 1H-NMR Solution Structure of the Antitryptic Core Peptide of Bowman-Birk Inhibitor Proteins: a minimal ‘canonical loop’ J. Biomol Struct. Dyn. 20, 59-70. 558KB
Scarpi, D., McBride, J.D. and Leatherbarrow R.J. (2002) Inhibition of Human b-Tryptase by Bowman-Birk Inhibitor Derived Peptides. J. Pept. Res. 59, 90-93 PDF_icon.gif (303 bytes) 68KB
Scarpi, D., Occhiato, E.G., Trabocchi, A., Leatherbarrow, R.J., Brauer, A.B.E., Nievo, M. and Guarna, A. (2001) Introduction of the New Dipeptide Isostere 7-Endo-BtA as Reverse Turn Inducer in a Bowman-Birk Proteinase Inhibitor: Synthesis and Conformational Analysis. Bioorg. Med. Chem. 9, 1625-1632 PDF_icon.gif (303 bytes) 587KB
McBride, J.D. & Leatherbarrow, R.J. (2001) Synthetic peptide mimics of the Bowman-Birk inhibitor protein. Curr. Med. Chem. 8, 909-917. PDF_icon.gif (303 bytes) 100KB
Brauer, A.B.E. , Kelly, G., McBride, J.D., Cooke, R.M., Matthews, S.J. & Leatherbarrow, R.J. (2001) The Bowman-Birk Inhibitor Reactive Site Loop Sequence Represents an Independent Structural b-Hairpin Motif. J. Mol. Biol. 306, 799-807.   PDF_icon.gif (303 bytes) 301KB
McBride, J.D, Freeman, H.N., Watson, E.M. & Leatherbarrow, R.J. (2000) Chymotrypsin Inhibitors Identified from a Second-Generation Template Assisted Combinatorial Peptide Library Proceedings of the 6th International Symposium on Solid Phase Synthesis and Combinatorial Chemical Libraries 1999 (Epton, R., ed) Mayflower Scientific press (in the press) PDF_icon.gif (303 bytes) 21KB
McBride, J.D., Freeman, H.N. & Leatherbarrow, R.J. (2000) Identification of Chymotrypsin Inhibitors from a Second-Generation Template Assisted Combinatorial Peptide Library. J. Pept. Sci. 6, 446-452. PDF_icon.gif (303 bytes) 89KB
Leatherbarrow, R.J. & Edwards, P.R. (1999) Analysis of Molecular Recognition using Optical Biosensors Current Opinion in Chemical Biology 3, 544-547. PDF_icon.gif (303 bytes) 212KB
McBride, J.D., Freeman, H.N.M. & Leatherbarrow, R.J. (1999) Selection of Human Elastase Inhibitors from a Conformationally-Constrained Combinatorial Peptide Library. Eur. J. Biochem. 266, 403-412. PDF_icon.gif (303 bytes) 422KB
Gariani, T. McBride, J.D. & Leatherbarrow, R.J. (1999) The role of the P2’ residue of Bowman-Birk inhibitors. Studies on P2’ variation in cyclic peptides encompassing the reactive site loop. Biochim. Biophys. Acta. 1431, 232-237. PDF_icon.gif (303 bytes) 167KB
McBride, J.D., Freeman, N. & Leatherbarrow, R.J. (1999) Selection of human elastase inhibitors from a conformationally-constrained combinatorial peptide library. Innovations and perspectives in solid phase synthesis and combinatorial libraries 1998 (Epton, R., ed) Mayflower Scientific press pp167-172. PDF_icon.gif (303 bytes) 484KB
McBride, J.D., Brauer, A.B.E., Nievo, M. & Leatherbarrow, R.J. (1999) Functional requirement for a threonine in the P2 position of a cyclic peptide mimetic of a Bowman-Birk proteinase inhibitor. Innovations and perspectives in solid phase synthesis and combinatorial libraries 1998 (Epton, R., ed) Mayflower Scientific press pp341-344. PDF_icon.gif (303 bytes) 255KB
McBride, J.D., Nievo, M., Brauer, A.B.E. & Leatherbarrow, R.J. (1998) The Role of Threonine in the P2 Position of Bowman-Birk Proteinase Inhibitors. Studies on P2 Variation in Cyclic Peptides Encompassing the Reactive Site Loop. J.Mol. Biol. 282, 447-458. PDF_icon.gif (303 bytes) 596KB
Edwards, P.R. Maule, C.H. Leatherbarrow, R.J. and Winzor, D.J. (1998) Second-order kinetic analysis of IAsys biosensor data: Its use and applicability. Anal. Biochem. 263, 1-12. PDF_icon.gif (303 bytes) 233KB
Hasan, Z. & Leatherbarrow, R.J. (1998) A Study of the Specificity of Barley Chymotrypsin Inhibitor 2 by Cysteine Engineering of the P1 Residue. Biochim. Biophys. Acta. 1384, 325-334. PDF_icon.gif (303 bytes) 115KB
Foord, R.L. & Leatherbarrow, R.J. (1998) Effect of Osmolytes on the Exchange Rates of Backbone Amide Protons in Proteins. Biochemistry 37, 2969-2978. PDF_icon.gif (303 bytes) 132KB
Hasan, Z. & Leatherbarrow, R.J. (1997) Introduction of Trypsin Specificity into Chymotrypsin Inhibitor II. Prot. Pept. Lett. 4, 335-342. PDF_icon.gif (303 bytes) 595KB
Edwards, P.R. & Leatherbarrow, R.J. (1997) Determination of Association Rate Constants by an Optical Biosensor using Initial Rate Analysis. Anal. Biochem. (1997) 246, 1-6. PDF_icon.gif (303 bytes) 126KB
Gariani, T. and Leatherbarrow, R.J. (1997) Stability of protease inhibitors based on the Bowman-Birk reactive site loop to hydrolysis by proteases. J Peptide Res. 49, 467-475. PDF_icon.gif (303 bytes) 673KB
Edwards, P.R., Lowe, P.A. & Leatherbarrow, R.J. (1997) Effect of surface loading upon the kinetics of protein-protein interactions as monitored by an optical biosensor. Journal of Molecular Recognition 10, 128-134. PDF_icon.gif (303 bytes) 227KB
McBride, J.D., Harbeck, B. and Leatherbarrow, R.J. (1996) Resin coupled peptides as proteinase inhibitors. Prot. Pept. Lett. 3, 193-198. PDF_icon.gif (303 bytes) 423KB
McBride, J.D., Freeman, N., Domingo, G.J. and Leatherbarrow, R.J. (1996) Selection of chymotrypsin inhibitors from a conformationally-constrained combinatorial library. J. Mol. Biol. 259, 819-827. PDF_icon.gif (303 bytes) 557KB
Edwards, P.R., Gill, A., Pollard-Knight, D.V., Leatherbarrow, R.J., Hoare, M. & Yeung, D. (1995) Kinetics of bimolecular complex formation at the surface of an optical biosensor. Anal. Biochem. 231, 210-217. PDF_icon.gif (303 bytes) 1,076KB
Domingo, G.J., Leatherbarrow, R.J., Freeman, N., Patel, S. & Weir, M. (1995) Synthesis of a mixture of cyclic peptides based on the Bowman-Birk reactive site loop to screen for serine protease inhibitors. Int. J. Peptide Protein Res. 46, 79-87. PDF_icon.gif (303 bytes) 1,301KB