Dr. Martine Demeunynck LEDSS Université Joseph Fourier BP 53 F38041 Grenoble Cedex 9 Tel : 33 76 51 44 29 Fax : 33 76 51 43 82

Fields of Interest:

Heterocyclic chemistry DNA recognition: Synthesis, reactivity and studies of active substances and model compounds that interact with DNA.

1. Synthesis of nitrogen heterocycles (purine, quinoline, acridine derivatives): intercalating antitumor drugs artificial nucleases or enzyme inhibitors Nitroxide labelled heterocycles Troeger's Bases as DNA chirality probes 2. Study of reactive intermediates: nitrenium, iminium, quinone-methide and quinone-imine-methide.

Selected references:

Concerning the mode of reaction of the proposed ultimated metabolite of the carcinogen 4-nitroquinoline-1-oxide. Evidence for intermediacy of nitrenium ions. J. Am. Chem. Soc., 1986, 3539-3541. Synthesis of N-acridinyl and N-Quinolinyl derivatives of radioprotective amino-thiols". Tetrahedron, 1989, 45, 6455-66 Synthesis and characterization of a new DNA-binding bifunctional Ruthenium (II) complex. Faraday Transactions, 1993, 89, 3261-69. "A new class of artificial nucleases that recognize and cleave apurinic sites in DNA with great selectivity and efficiency J. Amer. Chem. Soc., 1993, 115, 9952-59. Synthesis of purine-acridine hybrid molecules related to artificial endonucleases Tetrahedron, 1993, 49, 11237-52. "Synthesis of Troger's Base analogs derived from 3-aminoacridine and 10- aminobenzo[b][1,7]phenanthroline" Tetrahedron Lett.., 1995, 36, 1271-1274. "A phenanthrolino quinone methide: synthesis and study of precursors" J. Chem. Soc., Perkin Transactions I, 1995, in press.


DNA Heterocycles-Polyamides Anticancer-Antiviral Drugs Nucleases models Molecular Recognition