Dr. Josette Michon
LEDSS Université Joseph Fourier
F38041 Grenoble Cedex 9
Tel : 33 76 51 44 30
Fax : 33 76 51 43 82
Fields of Interest:
Molecular recognition: EPR studies using
1. Interaction of mono- and bi- nitroxide radicals with cyclodextrins.
2. Interaction with DNA of an endonuclease labelled with a nitroxide
Study of potentially anticancer drugs by EPR:
"Generation and identification of the amidyl radical resulting from homolytic N-O
cleavage in carcinogenic N-acetyl-N-(acyloxy)-2-aminofluorene"
J. Org. Chem., 1993, 6143-6145
"Electron spin resonance study of the complexation of long -(polyethylene glycol) chain
biradicals by gamma-cyclodextrins - Alkaline salts-induced changes"
New J. Chem., 1992, 915-918.
"Selective oxidation of beta-cyclodextrin by photochemical reaction with p-
Tet. Lett., 1992, 3315-3318.
"Kinetics of reduction of a nitroxide radical by ascorbic acid in the presence of beta-
cyclodextrin. Determination of the radical/beta-cyclodextrin association constant and rate
constants for reaction of the free and complexed nitroxide radical"
New J. Chem., 1988, 125-128.
EPR - spin labelling - spin trapping