Aldol Type Reactions of the Pyrrolidinone

  • Generation of the silyl enol ether (10) has allowed a variety of aldol type-reactions to be performed:

    Fluoride ion mediated aldol reactions.4

  • Line broadening occurs in the 1H NMR due to amide resonance, but high temperature NMR has improved the resolution of the peaks.

    Dehydration of the beta-hydroxy ketones to the enone has been achieved.

    Lewis Acid Mediated aldol reactions

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