Synthesis of pyridoquinolines (1)

Original route starting from o -aminobenyl alcohol ultimately failed to give the desired cycloadduct
poster 4a

R = H, Ph

Cyclisation possibly fails due to the conformation of the amide
poster 4b

However, molecular modelling has shown that the desired conformation can be acheived by alkylating or acylating the amide
poster 4c

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