Annelated pyridines as models for natural products

Initial aims were to prepare a range of simple analogues of the pyridoacridine marine alkaloids shown below
poster 2a

The synthetic strategy is be based on an intramolecular Diels - Alder reaction on the aza - butadiene with concomitant loss of dimethylamine to afford the desired adduct
poster 2b

R = H, Me, Ph, pyridyl, thiazoyl

X = N, O, S

Comparisons of the biological activity of these analogues with the natural products will be made

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