We would like to thank E.P.S.R.C and Zeneca Pharmaceuticals for their generous support of our research programme, and the E.P.S.R.C mass spectrometry service at Swansea for their assistance

I (DAR) would like to thank the following people for their thoughts and assistance thoughout my studies

Professor Chris Moody

Dr. Ian Waldron

The Fisons Lab and the Boys and Girls from F0001 F0009

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