Synthesis of the 4-Benzyl-Aca Linker
The 4-benzyl-Aca linker is similarly derived from 4-benzylcyclohexanone.  In this example, an achiral ketone is the precursor in this stereoselective synthesis of the desired lactam.  The oxaziridine are formed as previously described, however in this situation, the ring expansion yields a mixture of lactams that, when subject to Birch conditions, eventually leads to enantiomers.
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