Current Research
Within the subclass of the Gly-Gly model, we decided to examine the effect that C(2)-C(6) Aca linker monoalkylation has on the product macrocycle conformation.  Specifically, we chose to synthesize the benzyl substituted linker derivatives to alleviate solubility problems which previously hindered analysis of the related methylated substrates.

These cyclic tripeptides are now being subjected to NMR, CD, and X-ray crystallograpic analysis to determine their type and/or bias for type I/II b-turn conformations.  This poster describes the synthetic approaches toward the macrocycles and some preliminary results from X-ray crytallographic analysis.

Back to Index            Synthesis of (8S)-Benzyl-1,4,7-triazacyclotridecan-3,6,13-trione