$Version: 3 $Totobjs: 356 $Pen_RGB2Color: 0 0 0 $Fill_RGB2Color: 0 0 0 $Font: "Arial" 90 1 $Obj: mol $RxnAtch: -1 -1 $Obj: line $ArrowDir: 1 $ArrowStyle: 1 $Obj_coords: 1762 793 2730 794 $Obj: text $Transparent: $Obj_coords: 1800 644 2624 936 $MDLEdittext: 1 0012 {\rtf1\defformat\pc {\fonttbl {\f764\nil Arial;} {\f3992\nil Arial;} {\f1400\nil Arial;} {\f804\nil Arial;} {\f2332\nil Arial;} {\f440\nil Arial;} {\f2088\nil Arial;} } \plain \f2332\fs20\m HNO \plain \f440\fs20\dn6 \m 3 \plain \f2332\fs20\m /H \plain \f440\fs20\dn6 \m 2 \plain \f2332\fs20\m SO \plain \f440\fs20\dn6 \m 4 \plain \f2088\fs20 3:2 \plain \f2332\fs20\m \par \plain \f2332\fs20\m AcOH, \plain \f2088\fs20 12 \plain \f2332\fs20\m h } $Obj: mol $RxnAtch: -1 -1 $Obj: line $ArrowDir: 1 $ArrowStyle: 1 $Obj_coords: 3956 802 4675 802 $Obj: text $Transparent: $Obj_coords: 3962 690 4584 945 $MDLEdittext: 1 0012 {\rtf1\defformat\pc {\fonttbl {\f1072\nil Arial;} {\f1284\nil Arial;} {\f2084\nil Arial;} } \plain \f2084\fs20 MeI \plain \f2084\fs20 \par \plain \f2084\fs20 reflux, 4 days } $Obj: line $ArrowDir: 1 $ArrowStyle: 1 $Obj_coords: 314 2144 614 2144 $Obj: text $Transparent: $Obj_coords: 1617 2017 1692 2152 $MDLEdittext: 1 0012 {\rtf1\defformat\pc {\fonttbl {\f1092\nil Arial;} {\f920\nil Arial;} } \plain \f1092\fs18\b + } $Obj: text $Transparent: $Obj_coords: 1722 1957 1797 2129 $MDLEdittext: 1 0012 {\rtf1\defformat\pc {\fonttbl {\f3212\nil Arial;} {\f688\nil Arial;} } \plain \f3212\fs18\b I \plain \f688\fs18\b \up6 - } $Obj: line $ArrowDir: 1 $ArrowStyle: 1 $Obj_coords: 2150 2152 2862 2151 $Obj: mol $RxnAtch: -1 -1 $Obj: line $ArrowDir: 1 $ArrowStyle: 1 $Obj_coords: 284 3248 958 3245 $Obj: line $ArrowDir: 1 $ArrowStyle: 1 $Obj_coords: 2502 3252 3027 3255 $Obj: mol $RxnAtch: -1 -1 $Obj: mol $RxnAtch: -1 -1 $Obj: text $Transparent: $Obj_coords: 3820 4003 3835 4138 $MDLEdittext: 1 0012 {\rtf1\defformat\pc {\fonttbl {\f916\nil Arial;} {\f1980\nil Arial;} } \plain \f916\fs18\b } $Obj: text $Transparent: $Obj_coords: 2840 4791 2997 4956 $MDLEdittext: 1 0012 {\rtf1\defformat\pc {\fonttbl {\f1616\nil Arial;} {\f3240\nil Arial;} } \plain \f3240\fs24\b 2a } $Obj: mol $RxnAtch: -1 -1 $Obj: mol $RxnAtch: -1 -1 $Obj: text $Transparent: $Obj_coords: 3490 3778 3999 4190 $MDLEdittext: 1 0012 {\rtf1\defformat\pc {\fonttbl {\f1332\nil Arial;} {\f1828\nil Arial;} {\f2612\nil Arial;} {\f2120\nil Arial;} {\f3736\nil Arial;} {\f2784\nil Arial;} {\f1640\nil Arial;} {\f840\nil Arial;} {\f2052\nil Arial;} {\f1500\nil Arial;} } \plain \f3736\fs20\m NaBH \plain \f2784\fs20\dn6 \m 4 \plain \f2784\fs20\dn6 \m \par \plain \f1500\fs20\i i- \plain \f840\fs20 PrOH, r.t. \plain \f840\fs20 \par \plain \f840\fs20 4 h } $Obj: text $Transparent: $Obj_coords: 716 1424 1263 1566 $MDLEdittext: 1 0012 {\rtf1\defformat\pc {\fonttbl {\f1048\nil Arial;} {\f3496\nil Arial;} {\f2528\nil Arial;} } \plain \f2528\fs20\b papaverine } $Obj: line $ArrowDir: 1 $ArrowStyle: 1 $Obj_coords: 3627 3666 3357 4109 $Obj: text $Transparent: $Obj_coords: 2522 3030 2919 3510 $MDLEdittext: 1 0012 {\rtf1\defformat\pc {\fonttbl {\f2196\nil Arial;} {\f1832\nil Arial;} {\f676\nil Arial;} } \plain \f676\fs20 TBHP \plain \f676\fs20 \par \plain \f676\fs20 Triton-B \plain \f676\fs20 \par \plain \f676\fs20 THF, r.t. \plain \f676\fs20 \par \plain \f676\fs20 1h } $Obj: text $Transparent: $Obj_coords: 299 2869 898 3648 $MDLEdittext: 1 0012 {\rtf1\defformat\pc {\fonttbl {\f4048\nil Arial;} {\f2056\nil Arial;} {\f4064\nil Arial;} {\f2004\nil Arial;} {\f2920\nil Arial;} } \plain \f2004\fs20\m Fremy\'b4s \plain \f2004\fs20\m \par \plain \f2004\fs20\m salt \plain \f2004\fs20\m \par \plain \f2004\fs20\m K \plain \f2920\fs20\dn6 \m 2 \plain \f2004\fs20\m HPO \plain \f2920\fs20\dn6 \m 4 \plain \f2004\fs20\m \par \plain \f2004\fs20\m Me \plain \f2920\fs20\dn6 \m 2 \plain \f2004\fs20\m CO/H \plain \f2920\fs20\dn6 \m 2 \plain \f2004\fs20\m O \plain \f2004\fs20\m \par \plain \f2004\fs20\m r.t., \plain \f4064\fs20 1,5 \plain \f2004\fs20\m h \plain \f2004\fs20\m \par } $Obj: text $Transparent: $Obj_coords: 2164 2038 2786 2405 $MDLEdittext: 1 0012 {\rtf1\defformat\pc {\fonttbl {\f1016\nil Arial;} {\f976\nil Arial;} {\f344\nil Arial;} } \plain \f344\fs20 NaOH \plain \f344\fs20 \par \plain \f344\fs20 MeOH, reflux \plain \f344\fs20 \par \plain \f344\fs20 4 h } $Obj: atom $Parent: 0 $Atom_coords: 778.00000 702.00000 $Atom_number: 1 $Obj: atom $Parent: 0 $Atom_coords: 778.00000 856.00000 $Atom_number: 2 $Obj: atom $Parent: 0 $Atom_coords: 909.88458 933.00000 $Atom_number: 3 $Obj: atom $Parent: 0 $Atom_coords: 909.88446 625.00000 $Atom_number: 4 $Obj: bond $Pen_width: 7 $Bond_atoms: 25 28 $Bond_type: double $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 25 26 $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 26 27 $Bond_type: double $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 27 34 $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 39 28 $Bond_topo: arom $Obj: atom $Parent: 0 $Atom_coords: 1043.76904 856.00000 $Atom_number: 5 $Obj: atom $Parent: 0 $Atom_coords: 1176.51978 933.50000 $Atom_number: 6 $Obj: atom $Font: "Arial" 100 1 $Parent: 0 $Atom_coords: 1310.27051 856.00000 $Atom_type: 7 $Atom_number: 7 $Obj: atom $Parent: 0 $Atom_coords: 1310.27039 701.99994 $Atom_number: 8 $Obj: atom $Parent: 0 $Atom_coords: 1176.51978 625.49994 $Atom_number: 9 $Obj: atom $Parent: 0 $Atom_coords: 1043.76904 702.00000 $Atom_number: 10 $Obj: bond $Pen_width: 7 $Bond_atoms: 34 39 $Bond_type: double $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 34 35 $Bond_topo: arom $Bond_dbl_width: 1 $Obj: bond $Pen_width: 7 $Bond_atoms: 35 36 $Bond_type: double $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 36 37 $Bond_topo: arom $Bond_dbl_width: 1 $Obj: bond $Pen_width: 7 $Bond_atoms: 37 38 $Bond_type: double $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 38 39 $Bond_topo: arom $Bond_dbl_width: 1 $Obj: atom $Parent: 0 $Atom_coords: 1176.51978 1086.50000 $Atom_number: 11 $Obj: bond $Pen_width: 7 $Bond_atoms: 35 46 $Obj: bond $Pen_width: 7 $Bond_atoms: 46 49 $Obj: atom $Parent: 0 $Atom_coords: 1309.00000 1162.00000 $Atom_number: 12 $Obj: atom $Parent: 0 $Atom_coords: 1309.86853 1315.50427 $Atom_number: 13 $Obj: atom $Parent: 0 $Atom_coords: 1442.62402 1392.00427 $Atom_number: 14 $Obj: atom $Parent: 0 $Atom_coords: 1575.51099 1314.00000 $Atom_number: 15 $Obj: atom $Parent: 0 $Atom_coords: 1574.64246 1160.49573 $Atom_number: 16 $Obj: atom $Parent: 0 $Atom_coords: 1441.88696 1084.99573 $Atom_number: 17 $Obj: bond $Pen_width: 7 $Bond_atoms: 49 54 $Bond_type: double $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 49 50 $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 50 51 $Bond_type: double $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 51 52 $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 52 53 $Bond_type: double $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 53 54 $Bond_topo: arom $Obj: atom $Font: "Arial" 100 1 $Parent: 0 $Atom_coords: 645.11548 933.00000 $Atom_alias: "Me^O" $Atom_number: 18 $Obj: bond $Pen_width: 7 $Bond_atoms: 26 61 $Obj: atom $Font: "Arial" 100 1 $Parent: 0 $Atom_coords: 644.89996 626.37427 $Atom_alias: "Me^O" $Atom_number: 19 $Obj: bond $Pen_width: 7 $Bond_atoms: 25 63 $Obj: atom $Font: "Arial" 100 1 $Parent: 0 $Atom_coords: 1707.82678 1390.24890 $Atom_alias: "OMe" $Atom_number: 20 $Obj: bond $Pen_width: 7 $Bond_atoms: 52 65 $Obj: atom $Font: "Arial" 100 1 $Parent: 0 $Atom_coords: 1707.09216 1083.74670 $Atom_alias: "OMe" $Atom_number: 21 $Obj: bond $Pen_width: 7 $Bond_atoms: 53 67 $Obj: atom $Parent: 10 $Atom_coords: 3220.00000 2222.00000 $Atom_number: 2 $Obj: atom $Parent: 10 $Atom_coords: 3220.00000 2068.00000 $Atom_number: 3 $Obj: atom $Parent: 10 $Atom_coords: 3352.88452 1991.00000 $Atom_number: 4 $Obj: atom $Parent: 10 $Atom_coords: 3352.88452 2299.00000 $Atom_number: 5 $Obj: bond $Pen_width: 7 $Bond_atoms: 69 72 $Bond_type: double $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 69 70 $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 70 71 $Bond_type: double $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 71 78 $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 83 72 $Bond_topo: arom $Obj: atom $Parent: 10 $Atom_coords: 3485.76904 2068.00000 $Atom_number: 6 $Obj: atom $Parent: 10 $Atom_coords: 3619.51978 1991.50000 $Atom_number: 7 $Obj: atom $Parent: 10 $Atom_coords: 3752.27051 2068.00000 $Atom_number: 8 $Obj: atom $Parent: 10 $Atom_coords: 3752.27051 2222.00000 $Atom_number: 9 $Obj: atom $Parent: 10 $Atom_coords: 3619.51978 2298.50000 $Atom_number: 10 $Obj: atom $Parent: 10 $Atom_coords: 3485.76904 2222.00000 $Atom_number: 11 $Obj: bond $Pen_width: 7 $Bond_atoms: 78 83 $Bond_type: double $Bond_topo: arom $Bond_dbl_side: 2 $Bond_dbl_width: 1 $Obj: bond $Pen_width: 7 $Bond_atoms: 78 79 $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 80 79 $Bond_type: double $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 81 82 $Bond_type: double $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 82 83 $Bond_topo: arom $Obj: atom $Parent: 10 $Atom_coords: 3883.15527 2298.00000 $Atom_number: 12 $Obj: atom $Parent: 10 $Atom_coords: 4017.68848 2223.53906 $Atom_number: 13 $Obj: atom $Parent: 10 $Atom_coords: 4147.70996 2299.03198 $Atom_number: 14 $Obj: atom $Parent: 10 $Atom_coords: 4147.05176 2452.22998 $Atom_number: 15 $Obj: atom $Parent: 10 $Atom_coords: 3881.62842 2450.69360 $Atom_number: 17 $Obj: bond $Pen_width: 7 $Bond_atoms: 89 93 $Bond_type: double $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 89 90 $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 90 91 $Bond_type: double $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 91 92 $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 92 114 $Bond_type: double $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 114 93 $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 81 89 $Obj: atom $Font: "Arial" 100 1 $Parent: 10 $Atom_coords: 3619.51978 2451.50000 $Atom_type: 8 $Atom_number: 18 $Atom_dispflags: 0001 $Obj: bond $Pen_width: 7 $Bond_atoms: 82 101 $Obj: atom $Font: "Arial" 100 1 $Parent: 10 $Atom_coords: 3088.11548 1991.00000 $Atom_alias: "Me^O" $Atom_number: 19 $Obj: bond $Pen_width: 7 $Bond_atoms: 70 103 $Obj: atom $Font: "Arial" 100 1 $Parent: 10 $Atom_coords: 3087.89990 2297.62573 $Atom_alias: "Me^O" $Atom_number: 20 $Obj: bond $Pen_width: 7 $Bond_atoms: 69 105 $Obj: bond $Pen_width: 7 $Bond_atoms: 92 109 $Obj: bond $Pen_width: 7 $Bond_atoms: 81 80 $Bond_topo: arom $Obj: atom $Font: "Arial" 100 1 $Parent: 10 $Atom_coords: 4278.82666 2529.24902 $Atom_alias: "OMe" $Atom_number: 25 $Obj: bond $Pen_width: 7 $Bond_atoms: 90 111 $Obj: atom $Font: "Arial" 100 1 $Parent: 10 $Atom_coords: 4018.41895 2070.25342 $Atom_type: 35 $Atom_alias: "NO2" $Atom_number: 27 $Obj: bond $Pen_width: 7 $Bond_atoms: 114 113 $Obj: atom $Font: "Arial" 100 1 $Parent: 10 $Atom_coords: 4016.73267 2681.47705 $Atom_alias: "OMe" 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$Atom_coords: 3955.27051 3330.00000 $Atom_number: 9 $Obj: atom $Parent: 13 $Atom_coords: 3821.51978 3407.50000 $Atom_number: 10 $Obj: atom $Parent: 13 $Atom_coords: 3688.76904 3330.00000 $Atom_number: 11 $Obj: bond $Pen_width: 7 $Bond_atoms: 124 129 $Bond_type: double $Bond_topo: arom $Bond_dbl_side: 2 $Obj: bond $Pen_width: 7 $Bond_atoms: 124 125 $Bond_topo: ring $Obj: bond $Pen_width: 7 $Bond_atoms: 126 125 $Bond_topo: ring $Obj: bond $Pen_width: 7 $Bond_atoms: 127 128 $Bond_topo: ring $Obj: bond $Pen_width: 7 $Bond_atoms: 128 129 $Bond_topo: ring $Obj: atom $Parent: 13 $Atom_coords: 4086.15527 3407.00000 $Atom_number: 12 $Obj: atom $Parent: 13 $Atom_coords: 4219.68848 3331.53906 $Atom_number: 13 $Obj: atom $Parent: 13 $Atom_coords: 4349.70996 3407.03198 $Atom_number: 14 $Obj: atom $Parent: 13 $Atom_coords: 4349.05176 3560.22998 $Atom_number: 15 $Obj: atom $Parent: 13 $Atom_coords: 4084.62842 3559.69360 $Atom_number: 17 $Obj: bond $Pen_width: 7 $Bond_atoms: 135 139 $Bond_type: double $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 135 136 $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 136 137 $Bond_type: double $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 137 138 $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 138 164 $Bond_type: double $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 164 139 $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 127 135 $Obj: atom $Font: "Arial" 100 1 $Parent: 13 $Atom_coords: 3821.51978 3560.50000 $Atom_type: 8 $Atom_number: 18 $Atom_dispflags: 0001 $Obj: bond $Pen_width: 7 $Bond_atoms: 128 147 $Bond_type: double $Obj: atom $Font: "Arial" 100 1 $Parent: 13 $Atom_coords: 3290.11548 3100.00000 $Atom_alias: "Me^O" $Atom_number: 19 $Obj: bond $Pen_width: 7 $Bond_atoms: 116 149 $Obj: atom $Font: "Arial" 100 1 $Parent: 13 $Atom_coords: 3289.89990 3406.62573 $Atom_alias: "Me^O" $Atom_number: 20 $Obj: bond $Pen_width: 7 $Bond_atoms: 115 151 $Obj: bond $Pen_width: 7 $Bond_atoms: 138 155 $Obj: bond 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$Atom_coords: 3122.00000 700.00000 $Atom_number: 1 $Obj: atom $Parent: 3 $Atom_coords: 3122.00000 854.00000 $Atom_number: 2 $Obj: atom $Parent: 3 $Atom_coords: 3254.88452 930.00000 $Atom_number: 3 $Obj: atom $Parent: 3 $Atom_coords: 3254.88452 623.00000 $Atom_number: 4 $Obj: bond $Pen_width: 7 $Bond_atoms: 165 168 $Bond_type: double $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 165 166 $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 166 167 $Bond_type: double $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 167 174 $Bond_topo: arom $Obj: bond $Pen_width: 7 $Bond_atoms: 179 168 $Bond_topo: arom $Obj: atom $Parent: 3 $Atom_coords: 3388.76904 854.00000 $Atom_number: 5 $Obj: atom $Parent: 3 $Atom_coords: 3521.51978 930.50000 $Atom_number: 6 $Obj: atom $Font: "Arial" 100 1 $Parent: 3 $Atom_coords: 3654.27051 854.00000 $Atom_type: 7 $Atom_number: 7 $Obj: atom $Parent: 3 $Atom_coords: 3654.27051 699.99994 $Atom_number: 8 $Obj: atom $Parent: 3 $Atom_coords: 3521.51978 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