Dihydroquinazoline derivative

The Synthesis of the quinazoline derivative is performed in 12 M HCl using formaldehyde (1 equiv.). An almost quantitative reaction is observed as indicated by HPLC analysis, a 60% yield is obtained after purification. The quinazoline molecule is an intermediate in the formation of the Tröger's base. Reaction of the quinazoline derivative with excess of formaldehyde in 12 M HCl yields to the corresponding Tröger's base with nearly quantitative yield.