"While 288 variants (6 x 4 x 12) were targeted in principle for synthesis, a
concurrent refinement process
was implemented to select relatively optimal components for subsequent analogue
synthesis/evaluation. This process of using a "virtual" compound library
components to avoid the unnecessary synthesis and bioassay of weakly active
How do you decide which compounds to discard from the virtual library? What is
the nature of the "concurrent refinement process"? It seems to me that any
paradigm for compound exclusion would naturally lead to a biased library.
Michael A. Walters
ECHET96. Conference home page: http://www.ch.ic.ac.uk/ectoc/echet96/ using
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