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Chris Braddock read Chemistry at St Peter's College, Oxford and graduated with first class honours in 1992. He remained in Oxford to work with John Brown, FRS, for his doctorate which he obtained in January 1996. He was immediately appointed as a Fixed-Term Lecturer at Imperial College where he worked in Professor Tony Barrett's laboratories. In October 1998 he was appointed as a Lecturer in the newly created Synthesis section in the Department of Chemistry and initiated independent research. He was appointed to Senior Lecturer in 2005, and to Reader in 2008.

He was the winner of the Specialised Organic Chemicals Sector Association (SOCSA) 2000 Innovation Prize, the Royal Society of Chemistry Green Chemistry Jerwood Salters' Environment Award 2000, the Institute of Applied Catalysis (iAc) Award 2001 and the Pfizer award for teaching excellence 2002.